LETHALITY INDUCED BY STANNOUS CHLORIDE ON ESCHERICHIA COIL AB1157 - PARTICIPATION OF REACTIVE OXYGEN SPECIES

Authors
DANTAS FJS MORAES MO CARVALHO EF VALSA JO BERNARDO M CALDEIRADEARAUJO A
Citation
Fjs. Dantas et al., LETHALITY INDUCED BY STANNOUS CHLORIDE ON ESCHERICHIA COIL AB1157 - PARTICIPATION OF REACTIVE OXYGEN SPECIES, Food and chemical toxicology, 34(10), 1996, pp. 959-962
Citations number
22
Categorie Soggetti
Toxicology,"Food Science & Tenology
Journal title
Food and chemical toxicology → ACNP
ISSN journal
02786915
Volume
34
Issue
10
Year of publication
1996
Pages
959 - 962
Database
ISI
SICI code
0278-6915(1996)34:10<959:LIBSCO>2.0.ZU;2-5
Abstract
Stannous chloride (SnCl2) has been widely used in nuclear medicine as a reducing agent of pharmaceutical products radiolabelled with technet ium-99m. To verify whether the lethality induced by this salt could be mediated by reactive oxygen species (ROS), Escherichia coli cultures were treated with SnCl2 in the presence of catalase, ROS scavengers or metal-ion chelators. The inactivation effect, as measured by survival determination, was abolished by thiourea, sodium benzoate, dipyridyl or catalase. The results suggest the participation of ROS, generated b y a Fenton-like reaction, in the lethal effect induced by SnCl2. Copyr ight (C) 1996 Published by Elsevier Science Ltd.