EFFECT OF ACUTE ADMINISTRATION OF FISH-OIL (OMEGA-3 MARINE TRIGLYCERIDE) ON GASTRIC-ULCERATION AND SECRETION INDUCED BY VARIOUS ULCEROGENICAND NECROTIZING AGENTS IN RATS
Mm. Alharbi et al., EFFECT OF ACUTE ADMINISTRATION OF FISH-OIL (OMEGA-3 MARINE TRIGLYCERIDE) ON GASTRIC-ULCERATION AND SECRETION INDUCED BY VARIOUS ULCEROGENICAND NECROTIZING AGENTS IN RATS, Food and chemical toxicology, 33(7), 1995, pp. 553-558
The fish oil commercially known as Marine-25 (omega-3 marine triglycer
ide) is an eicosapentaenoic acid (EPA)-rich oil. It was investigated f
or its ability to inhibit gastric secretion and to protect the gastric
mucosa against the injuries caused by pyloric ligation, non-steroidal
anti-inflammatory drugs (NSAIDs-aspirin and indomethacin), reserpine,
hypothermic restraint stress and necrotizing agents [0.6 Mu HCl0.2 Mu
NaOH or 80% (v/v) aqueous ethanol]. The results showed that the fish
oil, at a dose of 5 or 10 ml/kg body weight, provided significant prot
ection in the various experimental models used. It produced a signific
ant inhibition of gastric mucosal damage induced by pyloric ligation,
NSAIDs, reserpine or hypothermic restraint ulcers. Fish oil also exert
ed a significant inhibitory action on gastric mucosal lesions produced
by various necrotizing agents. Our findings show that fish oil rich i
n eicosapentaenoic acid possesses both antisecretory and antiulcerogen
ic effects.