DETERMINATION OF ACIPIMOX IN CAPSULES BY DIFFERENTIAL-PULSE POLAROGRAPHY

A differential pulse polarographic (DPP) method has been developed for the determination of acipimox in its pharmaceutical formulations. Usi ng Sorensen buffer pH 6.0 as supporting electrolyte a single, irrevers ible peak occurred at - 0.79 V vs an Ag/AgCl reference electrode. The peak height vs concentration plot was found to be linear over the rang e of 10(-6) to 6 x 10(-4)mol/l. The detection limit is 60 ng/ml. The a nalysis of a series of 10 Olbetam(R) 250 mg capsules showed an overall standard deviation of +/- 4.18 mg and a S-rel of +/- 1.66%, respectiv ely.