EFFECTS OF DIETARY FATTY-ACID COMPOSITION ON BASAL AND HORMONE-STIMULATED HEPATIC LIPOGENESIS AND ON CIRCULATING LIPIDS IN THE RAT

Citation
A. Zampelas et al., EFFECTS OF DIETARY FATTY-ACID COMPOSITION ON BASAL AND HORMONE-STIMULATED HEPATIC LIPOGENESIS AND ON CIRCULATING LIPIDS IN THE RAT, British Journal of Nutrition, 74(3), 1995, pp. 381-392
Citations number
24
Categorie Soggetti
Nutrition & Dietetics
ISSN journal
00071145
Volume
74
Issue
3
Year of publication
1995
Pages
381 - 392
Database
ISI
SICI code
0007-1145(1995)74:3<381:EODFCO>2.0.ZU;2-K
Abstract
Thirty male rats were randomly assigned to one of three dietary groups in which the source of dietary fat was either a mixed oil, maize oil or fish oil. Effects of dietary fatty acid composition on in vitro rat es of [U-C-14]glucose incorporation into hepatic total lipids and into hepatic triacylglycerol were measured under basal, insulin (4 nM)-, g astric inhibitory polypeptide (GIP; 6 nM)- and insulin + GIP (4 nM + 6 nM)-stimulated conditions. Effects of the three diets on postprandial plasma triacylglycerol, cholesterol, insulin and GIP concentrations w ere also measured. The fish-oil diet decreased rates of basal glucose incorporation into hepatic total lipids (P < 0.05) and hepatic triacyl glycerol (P < 0.01) compared with the mixed-oil diet. The presence of insulin+GIP in the incubation medium stimulated glucose incorporation into hepatic total Lipids in the maize-oil (P < 0.01) and fish-oil gro ups (P < 0.05), as well as into hepatic triacylglycerol in the maize-o il group (P < 0.005). In addition, the fish-oil diet decreased postpra ndial plasma triacylglycerol levels compared with both other dietary g roups (P < 0.05 both cases), and the mixed-oil diet markedly increased postprandial plasma insulin levels compared with the other dietary gr oups (P < 0.001).