We describe two experiments that examine the knowledge and explanatory
processes of students in two medical schools with different modes of
instruction. One school had a conventional curriculum with basic scien
ce courses taught 1 1/2 years before the clinical training; the other
had a problem-based learning curriculum with basic science taught in t
he context of clinical problems and general problem-solving strategies
involving knowledge elaboration and hypothetico-deductive reasoning.
Both before and after being exposed to relevant basic science informat
ion, students were asked to provide diagnostic explanations of a clini
cal case. In this study, students in the problem-based learning curric
ulum reasoned in a manner consistent with the way they were taught, us
ing a backward directed pattern of reasoning and extensive elaboration
s based on detailed biomedical information. However, these students ha
d a greater tendency to commit errors of scientific fact, to generate
less coherent explanations, and to use flawed patterns of explanation,
such as circular reasoning. These results are viewed as reflecting th
e operation of two factors: context and method of instruction. The int
eraction between these factors is expressed in terms of the hypothesis
that basic science and clinical knowledge constitute two different wo
rlds.