The objective of process optimization in brewery fermentations is to b
uild up yeast concentrations sufficient to gain an optimal rate and ex
tent of attenuation and desired flavor development, while balancing, b
ut not overexpending, wort nutrients for growth and maintenance. In te
rms of process economics, two alternatives exist-moving to greater vol
ume accelerated-batch processing and applying small-scale, high-rate f
ermentation systems that are capable of being stepped up to meet peak
output when necessary. In the standard batch process, volumetric produ
ctivities are controlled mainly by cyclic variations in growth and fer
mentation rates and by the amount of yeast in suspension as a result o
f the gas-lift action taking place in the fermentor. Thus, fermentor d
esign must be optimized with respect to agitation and yeast concentrat
ion. Reduced process times may be achieved in cylindroconical vessels
because of increased movement within the fermentor. Unfortunately, hig
h degrees of agitation have been shown to give flavor problems. The ad
verse effects of agitation on beer quality may be prevented by operati
ng under fed-batch conditions. Another approach to improve volumetric
productivity is cell immobilization. With the successful application o
f immobilized yeast reactors for continuous beer maturation, as well a
s for the production of low-alcohol and nonalcoholic beers, one can ex
pect an increasing contribution of immobilized yeast systems to the de
velopment of a new process area in the brewing industry.