This paper considers the sustainability of the global agricultural sys
tem at acceptable levels of economic and environmental costs. A future
scenario of demand for food and fibre is outlined as the challenge co
nfronting the global agricultural system over the next 40 years. The c
apacity of the system to increase supply in response to this scenario
in an economically and environmentally sustainable manner in less deve
loped countries is considered. Five categories of agricultural resourc
es are investigated. Knowledge, which can be more readily developed th
an other resources, can be substituted for natural resources. Of each
resource, it is therefore asked whether knowledge has the capacity to
substitute for agricultural resources to increase supply in a sustaina
ble manner. The demand scenario will only be met in a sustainable way
with improved knowledge which may compensate for insufficient supplies
of natural resources. As knowledge can only grow through investment i
n its development, a strategy to control and manage the allocation of
investments to various sectors is required if a sustainable global agr
icultural system is to be developed.