SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY DETERMINATIONS OF SOME N-(SUBSTITUTED 1-HYDROXYMETHYLPHENYL)-1,2,3,6-TETRAHYDROPYRIDINES

Several novel N-(substituted 1-hydroxymethylphenyl)-1,2,3,6-tetrahydro pyridines were synthesized via sodium borohydride reduction of the cor responding N-(substituted phenylcarbonylimino)-4-benzoylpyridinium yli des in absolute ethanol. The anti-inflammatory activities using the ca rrageenan-induced rat paw edema assay and hyperglycemic effects measur ed by determining the rat blood glucose levels of these compounds were investigated. The unsubstituted derivative, (1-hydroxymethylphenyl)-1 ,2,3,6-tetrahydropyridine (6a) and 1-hydroxymethyl-phenyl)-1,2,3,6-tet rahydropyridine (6e) were found to be the most active anti-inflammator y agents and their effects were comparable to that of indomethacin, th e reference compound. AU the compounds tested displayed moderate to go od hyperglycemic activities.