NUTRIENT-SPECIFIC EFFECTS OF MODIFIED SHAM-FEEDING ON PANCREATIC-POLYPEPTIDE RELEASE

Objective: To study the effect of meal composition on pancreatic polyp eptide release during modified sham feeding. Design: In random order a nd on separate occasions, isocaloric, isothermic, iso-osmotic, homogen ized meals (1050 kJ; 250 kcal) either rich in fat (walnuts; 64 g fat, 7g protein, 15g starch per 100g), protein (codfish; 1g fat, 23g protei n per 100g) or carbohydrates (bananas; 22 g starch, 1 g protein per 10 0 g) were sham-fed for 30min by tasting and spitting out the meal. The plasma pancreatic polypeptide response was monitored by radioimmunoas say at 10min intervals from 20min before to 120 min after modified sha m feeding. Setting: Department of Gastroenterology and Hepatology of a University Hospital. Subjects: Seven healthy volunteers: 3 male, 4 fe male; age 45 (range 30-77) years. Results: Integrated plasma pancreati c polypeptide responses to modified sham feeding of codfish (1088 +/- 395 pM120min; P < 0.05) and walnuts (1200 +/- 542 pM*120 min) were di stinctly higher (P < 0.05) than to modified sham feeding of bananas (- 390 +/- 291 pM 120 min). Conclusions: These results demonstrate that the pancreatic polypeptide response to modified sham feeding is depend ent on the composition of the meal.