At relatively large scattering angles, Z-dependent effects occur in bo
th the atomic (elastic or quasi-elastic) electron scattering and in th
e inelastic electron-electron scattering and can thus exhibit chemical
contrast at high spatial resolution. Results are shown for secondary
electron imaging of semiconductor multilayers in both bulk specimens a
nd in transmission specimens. Variations in electron-electron scatteri
ng or stopping power can contribute to ADF images in the STEM and it m
ay be useful to apply energy filtering as well as energy selection in
their collection.