IMMUNE AND PHYSIOLOGICAL-RESPONSES OF TURKEYS WITH GREEN-LIVER OSTEOMYELITIS COMPLEX

Citation
Gr. Bayyari et al., IMMUNE AND PHYSIOLOGICAL-RESPONSES OF TURKEYS WITH GREEN-LIVER OSTEOMYELITIS COMPLEX, Poultry science, 76(2), 1997, pp. 280-288
Citations number
47
Categorie Soggetti
Agriculture Dairy & AnumalScience
Journal title
ISSN journal
00325791
Volume
76
Issue
2
Year of publication
1997
Pages
280 - 288
Database
ISI
SICI code
0032-5791(1997)76:2<280:IAPOTW>2.0.ZU;2-U
Abstract
A study of field turkeys was undertaken in order to determine the invo lvement of relative immunological differences in the etiology of turke y osteomyelitis complex (TOC). Lame and normal turkeys were sampled fr om commercial flocks just prior to processing in two separate trials. After testing for functions of both humoral and cellular immunity, the turkeys were necropsied and examined for lesions of TOC. There were s ignificantly higher relative spleen and liver weights and significantl y lower body weights and relative bursal weights in birds with TOC. Th e birds with TOC had lower response to phytohemagglutinin-P in both in vivo and in vitro tests as well as lower circulating lymphocyte count s and higher monocyte, heterophil, and total white blood cell counts. There was a significantly higher antibody response to sheep red blood cells in turkeys with TOC, whereas antibody response to Salmonella pul lorum antigen was not different. There were no significant differences in the percentages of mononuclear cells or heterophils able to phagoc ytize bacteria or latex particles, or kill bacteria; however, the hete rophils from turkeys with TOC lesions did phagocytize significantly fe wer latex particles per cell than did those of the healthy turkeys. To tal serum protein, uric acid, and blood urea nitrogen levels were high er in birds with TOC, whereas hemoglobin, iron, alkaline phosphatase, and gamma-glutamyl-transferase levels were lower. Although many of the differences in birds with TOC could be caused by the normal host reac tion to infection, further study may reveal innate differences that co ntribute to susceptibility to TOC.