M. Gajdova et al., DELAYED-EFFECTS OF NEONATAL EXPOSURE TO TWEEN-80 ON FEMALE REPRODUCTIVE-ORGANS IN RATS, Food and chemical toxicology, 31(3), 1993, pp. 183-190
Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1,
5 or 10% aqueous solution on days 4-7 after birth. Treatment with Twe
en 80 accelerated maturation, prolonged the oestrus cycle, and induced
persistent vaginal oestrus. The relative weight of the uterus and ova
ries was decreased relative to the untreated controls. Squamous cell m
etaplasia of the epithelial lining of the uterus and cytological chang
es in the uterus were indicative of chronic oestrogenic stimulation. O
varies were without corpora lutea, and had degenerative follicles.