DELAYED-EFFECTS OF NEONATAL EXPOSURE TO TWEEN-80 ON FEMALE REPRODUCTIVE-ORGANS IN RATS

Authors
GAJDOVA M JAKUBOVSKY J VALKY J
Citation
M. Gajdova et al., DELAYED-EFFECTS OF NEONATAL EXPOSURE TO TWEEN-80 ON FEMALE REPRODUCTIVE-ORGANS IN RATS, Food and chemical toxicology, 31(3), 1993, pp. 183-190
Citations number
14
Categorie Soggetti
Toxicology,"Food Science & Tenology
Journal title
Food and chemical toxicology → ACNP
ISSN journal
02786915
Volume
31
Issue
3
Year of publication
1993
Pages
183 - 190
Database
ISI
SICI code
0278-6915(1993)31:3<183:DONETT>2.0.ZU;2-A
Abstract
Neonatal female rats were injected ip (0.1 ml/rat) with Tween 80 in 1, 5 or 10% aqueous solution on days 4-7 after birth. Treatment with Twe en 80 accelerated maturation, prolonged the oestrus cycle, and induced persistent vaginal oestrus. The relative weight of the uterus and ova ries was decreased relative to the untreated controls. Squamous cell m etaplasia of the epithelial lining of the uterus and cytological chang es in the uterus were indicative of chronic oestrogenic stimulation. O varies were without corpora lutea, and had degenerative follicles.