BIOCHEMICAL AND STRUCTURAL ALTERATIONS IN RAT ERYTHROCYTES DUE TO HEXACHLOROCYCLOHEXANE EXPOSURE

Authors
AGRAWAL D SULTANA P
Citation
D. Agrawal et P. Sultana, BIOCHEMICAL AND STRUCTURAL ALTERATIONS IN RAT ERYTHROCYTES DUE TO HEXACHLOROCYCLOHEXANE EXPOSURE, Food and chemical toxicology, 31(6), 1993, pp. 443-448
Citations number
28
Categorie Soggetti
Toxicology,"Food Science & Tenology
Journal title
Food and chemical toxicology → ACNP
ISSN journal
02786915
Volume
31
Issue
6
Year of publication
1993
Pages
443 - 448
Database
ISI
SICI code
0278-6915(1993)31:6<443:BASAIR>2.0.ZU;2-A
Abstract
The changes in biochemical constituents of rat erythrocyte membranes w ere observed after a single ip exposure to 300 mg commercial HCH/kg bo dy weight (one-third of the LD50). The phospholipid:cholesterol ratio was altered, and there were changes in the activities of the membrane- bound enzymes ATPase and acetylcholinesterase. The phospholipid conten t was increased while cholesterol and ATPase and acetylcholinesterase activities were significantly decreased. The erythrocytes also showed morphological changes (cell deformity and echinocyte formation).