EXPERIMENTAL-DESIGNS, STATISTICS AND INTERPRETATION

The Working Group on Experimental Designs, Statistics and Interpretati on considered the use of statistics in combination toxicology, the ter minology used to describe the interaction(s) of chemicals, the use of efficient experimental designs to minimize animal use, the diverse int erests and goals covered by combination toxicology and approaches usef ul for complex mixtures. The importance of the use of appropriate expe rimental designs and statistical methodology was recognized. Given the present lack of consensus on terminology and methodology, it is recom mended that investigators provide in their publications the definition of additivity and the mathematical model being used.