The boundary subsystem of a living system protects the components of t
he system from environmental stresses, filtering inputs and outputs of
various sorts of matter. energy, and information. The boundary provid
es several layers of protection; the innermost layer is the subsystem
of immunity reactions and error correction processes. This immunity su
bsubsystem (IS) is generated by the genetic template in cells, organs,
and organisms but must be carefully designed for organizations, commu
nities, and societies. This paper examines principles and pathologies
of IS structure and process in organisms and explores their applicabil
ity to the design of the IS for organizations.