For over 35 years, an independent panel of expert scientists has serve
d as the primary body for evaluating the safety of flavour ingredients
. This group, the Expert Panel of the Flavor and Extract Manufacturers
' Association (FEMA), has achieved international recognition from the
flavour industry, government regulatory bodies including the Food and
Drug Administration, and the toxicology community for its unique contr
ibutions. To date, the Expert Panel has evaluated the safety of more t
han 1700 flavour ingredients and determined the vast majority to be ''
generally recognized as safe'' (GRAS). Elements that are fundamental t
o the safety evaluation of flavour ingredients include exposure, struc
tural analogy, metabolism, pharmacokinetics and toxicology. Flavour in
gredients are evaluated individually taking into account the available
scientific information on the group of structurally related substance
s. The elements of the GRAS assessment program as they have been appli
ed by the Expert Panel to the group of 119 alicyclic substances used a
s flavour ingredients, and the relevant scientific data which provide
the basis for the GRAS status of these substances, are described herei
n. This publication is the first of a series on GRAS flavour ingredien
ts. Copyright (C) 1996 Published by Elsevier Science Ltd