Three simple, sensitive and reproducible visible spectrophotometric me
thods (A-C) for the determination of mebeverine hydrochloride (MVH) in
bulk samples and pharmaceutical formulations are described. Methods A
and B are based on the formation of ion-association complexes between
the drug and fast green FCF (FGFCF, lambda(max) 625nm) or bromothymol
blue (BTB, lambda(max) 405nm). Method C is based on the formation of
a molecular complex between the drug and cobalt thiocyanate (CTC, lamb
da(max) 625nm). Regression analysis of Beer's plots showed good correl
ation in the concentration ranges 2-40, 2-25 and 100-600 mu g/ml for m
ethods A,B and C respectively. No interference was observed from the u
sually existing additives in pharmaceutical formulations and the appli
cability of the methods was examined by analysing tablets containing M
VH. Standard deviations were typically less than or equal to 0.75 mg p
er dose (RSD: 0.25-0.5%). Recoveries were 99.0-100.2%.