SYNTHESIS AND RECEPTOR-BINDING OF N-SUBSTITUTED-2-STYRYL-1,2,3,6-TETRAHYDROPYRIDINES AS POTENTIAL NICOTINIC AGONISTS

The synthesis of a series of N-substituted styryl-tetrahydropyridine d erivatives is reported. The biological activity of these compounds was evaluated in vitro against both nicotinic and muscarinic receptors de rived from rat cerebral cortex. The methyl derivative 6a shows binding affinity for central nicotinic receptors in the micromolar range.