WHOLE-BODY AND REGIONAL BODY-COMPOSITION ANALYSIS BY DUAL-ENERGY X-RAY ABSORPTIOMETRY IN CIRRHOTIC-PATIENTS

Objectives: To compare whole body and regional (arms, legs and trunk) fat mass, fat-free mineral-free mass, bone mineral content and bone mi neral density, measured by DXA, in cirrhotic patients and age, sex and BMI matched healthy volunteers. Design: Cross-sectional study. Settin g: Two medical research institutions. Subjects: Twenty-two non ascitic cirrhotic patients and 16 age, sex and BMI matched healthy volunteers . Interventions: The Lunar DPX whole-body X-ray densitometer with Luna r software version 3.6z (Lunar Radiation Corp., Madison WI, USA) was u sed. Regional analysis was performed on the arms, legs, trunk and head . Results: Compared to controls, cirrhotic patients showed a significa nt reduction in percentage body fat. When differentiated by gender, ho wever, the reduction in percentage body fat was evident in female cirr hotics only, particularly in the trunk. In male cirrhotic patients fat -free mineral-free mass was reduced in absolute terms in the whole bod y and the limbs. For both genders and in each body segment bone minera l content and density were reduced in cirrhotics compared to controls. In cirrhotic patients bone mineral density was significantly correlat ed to both fat-free, mineral-free mass (r=0.85; P<0.001) and to the Ph ysical Activity Index (r=0.52; P<0.01). Conclusions: Two different pat terns of soft tissue loss may be found in cirrhotic patients: in women lean tissue is maintained while fat stores are reduced, as in early s tarvation; in men lean tissue is reduced, as seen under conditions of stress. Moreover, factors influencing lean body mass, such as nutritio nal depletion and physical inactivity, may contribute to the reduction of bone density frequently observed in cirrhotic patients.