No. Mocchiutti et Ca. Bernal, EFFECTS OF CHRONIC DI(2-ETHYLHEXYL) PHTHALATE INTAKE ON THE SECRETIONAND REMOVAL RATE OF TRIGLYCERIDE-RICH LIPOPROTEINS IN RATS, Food and chemical toxicology, 35(10-11), 1997, pp. 1017-1021
This work intends to characterize the nature of the plasma triglycerid
e level decrease in male Wistar rats fed with diets supplemented with
2% (w/w) di(2-ethylhexyl) phthalate (DEHP), a packaged-food chemical c
ontaminant. After being fed for 21 days, the animals were assessed to
determine plasma and liver lipids or to quantify the in vivo hepatic s
ecretion and in vitro plasma removal of triglyceride-rich lipoproteins
. The liver cholesterol and triglyceride contents in DEHP-fed rats wer
e closely similar to those found in controls, co-existing with a decre
ase in plasma cholesterol (19%), phospholipid (14%) and triglyceride (
36%) levels. The decrease of the plasma triglyceride pool size was not
associated with a reduction in hepatic secretion of triglyceride. The
total triglyceride lipase activity rose (32%) due to a remarkable inc
rease (100%) of the extrahepatic lipoprotein lipase activity. We can c
onclude that extrahepatic lipoprotein lipase activity accounts for the
hypotriglyceridaemic effect of DEHP through an increase of triglyceri
de removal rate. (C) 1997 Elsevier Science Ltd. All rights reserved.