N. Lakshmanan et Sj. Lamont, RFP-Y REGION POLYMORPHISM AND MAREKS-DISEASE RESISTANCE IN MULTITRAITIMMUNOCOMPETENCE-SELECTED CHICKEN LINES, Poultry science, 77(4), 1998, pp. 538-541
Although the influence of the chicken classical MHC in resistance to m
any diseases is well established, the role of the recently identified,
genetically independent, MHC-like region known as Rfp-Y is unclear. T
he objectives of this study were to analyze the frequencies of DNA pol
ymorphisms of the Rfp-Y region in White Leghorn lines, which were dive
rgently selected in replicate for multitrait immunocompetence, and to
determine the association of these polymorphisms with Marek's disease
(MD) resistance. Chicks, either with or without herpes virus of turkey
(HVT) vaccination, were challenged with 500 ffu of a very virulent Ma
rek's disease virus (Md5) at 2 d of age. The MD-related data were coll
ected for 10 wk. PvuII-digested genomic DNA was hybridized with an Rfp
-Y region-specific probe, 18.1. Three Rfp-Y polymorphisms were observe
d. The frequency of one Rfp-Y polymorphism was significantly different
between divergently selected multitrait immunocompetence lines in one
replicate only; therefore, the impact of multitrait immunocompetence
selection on Rfp-Y polymorphisms is inconclusive. The PvuII defined Rf
p-Y region polymorphisms had no association with either innate or vacc
ine-induced MD resistance to Md5 virus challenge.