This paper examines the mechanisms adopted by R&D-intensive firms to a
ppropriate value from research capabilities. New technical opportuniti
es, innovation options, can be exploited through internal development
or through their exchange in intermediate knowledge markets. An analys
is of biopharmaceutical research projects demonstrates that transactio
n cast hazards manifest themselves in both the internal and market-med
iated alternatives. The impact of information asymmetry conditions is
found to be contingent on firm capabilities; firms with high levels of
development-related resources demonstrate a negative relationship bet
ween information asymmetry conditions and reliance on market exchange,
while firms with low levels of such resources demonstrate a positive
relationship. (C) 1998 Elsevier Science B.V.