RAPID CHYLOMICRON APPEARANCE FOLLOWING SEQUENTIAL MEALS - EFFECTS OF 2ND MEAL COMPOSITION

Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-ric h meals. An earlier study has shown that the triacylglycerol in this e arly peak originates from a previous meal. The present study was perfo rmed to investigate the effects of different second meals on the plasm a triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested on e of the following in a balanced design: a fat-rich meal, a low-fat me al, water or nothing by mouth. Blood samples were taken for 2.5 h foll owing the second meal. An early peak in chylomicron and plasma triacyl glycerol concentrations was seen following both low-fat and fat-rich s econd meals but not following water. During studies investigating post prandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.