K. Evans et al., RAPID CHYLOMICRON APPEARANCE FOLLOWING SEQUENTIAL MEALS - EFFECTS OF 2ND MEAL COMPOSITION, British Journal of Nutrition, 79(5), 1998, pp. 425-429
Previous studies have noted the presence of an early postprandial peak
in plasma triacylglycerol concentrations following successive fat-ric
h meals. An earlier study has shown that the triacylglycerol in this e
arly peak originates from a previous meal. The present study was perfo
rmed to investigate the effects of different second meals on the plasm
a triacylglycerol response. Six healthy subjects were studied on four
occasions each. At 5 h following a fat-rich breakfast they ingested on
e of the following in a balanced design: a fat-rich meal, a low-fat me
al, water or nothing by mouth. Blood samples were taken for 2.5 h foll
owing the second meal. An early peak in chylomicron and plasma triacyl
glycerol concentrations was seen following both low-fat and fat-rich s
econd meals but not following water. During studies investigating post
prandial lipaemia, further meals must be avoided, even if they contain
no fat, although water may be allowed.