NOVEL DOPAMINE TRANSPORTER LIGANDS - THE STATE-OF-THE-ART

The dopamine transporter has served as the primary molecular target fo r the development of potential pharmacotherapeutic treatments for coca ine-abuse. The evolution of structure-activity relationships, within v arious classes of dopamine uptake inhibitors, has provided selective m olecular probes to study the dopamine transporter. Ultimately, the elu cidation of structure and function of this protein will undoubtedly pr ovide new leads toward treatment of cocaine addiction.