We discuss various measures of urban-versus-rural character, particula
rly when used for adjustment of epidemiologic or environmental data. F
or example, because urban-versus-rural differences may conceal more su
btle effects, such a measure may be used to adjust for urban-versus-ru
ral differences in county mortality rates, so that underlying geograph
ic or demographic patterns may be revealed. Urban-versus-rural measure
s frequently have been defined as categorical variables given by range
s of (i) total population; (ii) population density; and (iii) percent
urban population. When regions are counties in the United States, such
measures are easily obtained, but their relation to one's concept of
urban-versus-rural character is often weak, as illustrated with severa
l examples. A class of alternative measures is proposed. These measure
s are functions of the individual populations of places (usually minor
civil divisions) in the county: (1) population of the largest place;
(2) root sum of squared populations of three largest places; and (3) r
oot sum of squared populations of all places. Two members of this clas
s already have shown promise in statistical analyses of lung cancer mo
rtality rates, namely (1) and (2). Using U.S. county data, we demonstr
ate that (3) adds only very marginal information to the measure, and t
hat (2), which we call urbanicity, is useful for purposes of adjustmen
t in studies of ecological exploration.