Bacterial pathogens play an important role in causing respiratory dise
ase in domestic poultry species. In many cases, the bacterial componen
t of a respiratory disease colonizes the respiratory system only after
a primary viral or environmental insult. Colonization of the airsacs
of a chicken by Escherichia coli following an infectious bronchitis vi
rus infection is an example of secondary bacterial invasion. In other
cases, the bacterial component of the respiratory disease is the prima
ry initiating cause of the disease. Examples of primary bacterial resp
iratory disease are infectious coryza in chickens and fowl cholera in
chickens and turkeys.