RETROGRADED HIGH-AMYLOSE CORN STARCH REDUCES CHOLIC-ACID EXCRETION FROM THE SMALL-BOWEL IN ILEOSTOMY SUBJECTS

Objective: To study the short-term effect of resistant starch (RS) fro m retrograded high-amylose corn starch (HACS) on the excretion of bile acids and nutrients from the small bowel in humans. Design: Seven hea lthy ileostomists were given a controlled, constant diet during three days. On days 2 and 3, 100 g/d of one of two test-products-drum-dried ordinary corn starch and autoclaved retrograded HACS, providing 5 and 39 g RS/d, respectively-was given, in random order. Ileostomy effluent s were collected for 24 h per day and analysed for wet weight, dry wei ght, energy, bile acids and nutrients. Settings: In-patient study at t he metabolic ward, Department of Clinical Nutrition, Sahlgrenska Unive rsity Hospital, Goteborg. Results: Consumption of retrograded HACS cau sed (I) a 42% lower mean excretion of cholic acid (P = 0.024); (2) a 4 2% lower mean wet weight concentration of bile acids (P < 0.001); (3) a 70% increased excretion of dry weight (P = 0.001); and (4) a 41% inc reased excretion of energy (P = 0.036) compared with consumption of dr um-dried ordinary corn starch. Conclusion: The reduced ileal excretion and concentration of cholic acid would be protective regarding colon cancer risk in addition to the increased fermentation substrate provid ed by RS and other energy-yielding components.