RETINOIDS AS POTENTIAL CHEMOTHERAPEUTIC-AGENTS - SYNTHESIS, CYTOSTATIC AND DIFFERENTIATING ACTIVITIES OF NEW HETEROCYCLIC-ANALOGS OF RETINOIC ACID

The synthesis of a new class of heterocyclic analogues of retinoids an d their cytostatic and differentiating activities against HL-60 cells are reported. Several of the tested compounds (i.e. 7c, 7e, and 7f) we re markedly more cytostatic to HL-60 than other tumor cell lines, poin ting to a specific effect on HL60 differentiation that is distinct fro m the general cytostatic property of the test compounds. These heteror etinoids may be considered as candidate drugs for the therapy of cance r, psoriasis and cutaneous aging.