EFFECTS OF DIETHYLAMINOETHYL)AMINO-1,3,5(10)-ESTRATRIEN-3-OL, AND ITSANDROSTANE ANALOG ON BLOOD-CLOTTING TIME

The 17 beta-diamino-steroids 17 iethylaminoethyl)-amino-1,3,5,(10)-est ratrien-3-ol 2 and its androstane analog 17 beta-(N,N-diethylaminoethy l)-amino-5 alpha-androstan-3 beta-ol 3, were prepared and tested for a nticoagulant activity. A single subcutaneous administration of compoun d 2, produced in adult male mice, dose-dependent increases in blood cl otting times. The androstane analog 5 had no anticoagulant effect at e quivalent and higher doses. Aromaticity of ring A and/or absence of th e 19 methyl group may to be necessary for anticoagulant effect. The as say of 2 on vaginal cornification and uterine weight showed a moderate estrogenic activity.