4-[OMEGA-(TETRALIN-1-YL)ALKYL]-1-BENZYLPIPERAZINES AND RELATED-COMPOUNDS AS 5-HT1A D-2 LIGANDS/

Authors
PERRONE R BERARDI F COLABUFO NA LEOPOLDO M LOGRANO MD TORTORELLA V
Citation
R. Perrone et al., 4-[OMEGA-(TETRALIN-1-YL)ALKYL]-1-BENZYLPIPERAZINES AND RELATED-COMPOUNDS AS 5-HT1A D-2 LIGANDS/, Medicinal chemistry research, 7(2), 1997, pp. 76-86
Citations number
23
Categorie Soggetti
Chemistry Medicinal
Journal title
Medicinal chemistry research → ACNP
ISSN journal
10542523
Volume
7
Issue
2
Year of publication
1997
Pages
76 - 86
Database
ISI
SICI code
1054-2523(1997)7:2<76:4AR>2.0.ZU;2-H
Abstract
N-Benzylpiperazine and -piperidine derivatives of long-chain piperazin e were synthesized in order to obtain putative atypical antipsychotic agents with a dual 5-HT1A/D-2 affinity and reduced, or without, al adr energic affinity. The 5-HT1A/D-2/alpha(1) receptor binding results sho w that only compound 30, ,4-tetrahydronaphthalen-1-yl)-n-propyl]pipera zine, has an acceptable binding affinity profile (pK(i) = 7.9, 7.1, 6. 7, respectively).