CARBOXYL-PROMOTED ENHANCEMENT OF SELECTIVITY FOR THE BETA(3) ADRENERGIC-RECEPTOR - SELECTIVITY IS ENHANCED AT THE LEVEL OF RECEPTOR-BINDING

Authors
SHER PM FISHER LG SKWISH S MICHEL IM SEILER SM WASHBURN WN DICKINSON KEJ
Citation
Pm. Sher et al., CARBOXYL-PROMOTED ENHANCEMENT OF SELECTIVITY FOR THE BETA(3) ADRENERGIC-RECEPTOR - SELECTIVITY IS ENHANCED AT THE LEVEL OF RECEPTOR-BINDING, Medicinal chemistry research, 7(2), 1997, pp. 109-115
Citations number
23
Categorie Soggetti
Chemistry Medicinal
Journal title
Medicinal chemistry research → ACNP
ISSN journal
10542523
Volume
7
Issue
2
Year of publication
1997
Pages
109 - 115
Database
ISI
SICI code
1054-2523(1997)7:2<109:CEOSFT>2.0.ZU;2-L
Abstract
Four carboxyl-containing, selective beta(3) adrenergic agonists and th eir ester or amide derivatives were evaluated for their ability to bin d to human beta(1), beta(2), and beta(3) adrenergic receptors. Stimula tory effects on the beta(3) adrenergic receptor were also measured. We conclude that carboxyl-derived beta(3) functional selectivity Likely results, at least in part, from the effect of the carboxyl on binding selectivity.