HYBRIDIZATION OF ANTIOXIDANT AND CALCIUM-UPTAKE INHIBITORY PHARMACOPHORES

Authors
GERE A AGAICSONGOR E GIZUR T DOMANY G
Citation
A. Gere et al., HYBRIDIZATION OF ANTIOXIDANT AND CALCIUM-UPTAKE INHIBITORY PHARMACOPHORES, Medicinal chemistry research, 7(3), 1997, pp. 192-198
Citations number
22
Categorie Soggetti
Chemistry Medicinal
Journal title
Medicinal chemistry research → ACNP
ISSN journal
10542523
Volume
7
Issue
3
Year of publication
1997
Pages
192 - 198
Database
ISI
SICI code
1054-2523(1997)7:3<192:HOAACI>2.0.ZU;2-W
Abstract
Hybridization of the structures of the antioxidant 2,6-bis(1,1-dimethy lethyl)-4-methylpheno (BHT, 1) and the calcium uptake inhibitors medib azine (2), lomerizine (3), cinnarizine (4) and flunarizine (5) resulte d in compounds (6-9) with dual activity. The inhibitory effects of the parent compounds were retained in lipid peroxidation (induced either by NADPH or Fe2+) and in veratrine-evoked Ca-45 uptake, but inhibitory activity was decreased in K+ stimulated Ca-45 uptake.