SCANNING TUNNELING INVESTIGATION OF DNA STRUCTURES INVOLVED IN GENE-REGULATION

Authors
PASERO P BLETTRY C MARILLEY M JORDAN B GRANJEAUD S DAYEZ M HUMBERT A
Citation
P. Pasero et al., SCANNING TUNNELING INVESTIGATION OF DNA STRUCTURES INVOLVED IN GENE-REGULATION, Journal of vacuum science & technology. B, Microelectronics and nanometer structures processing, measurement and phenomena, 12(3), 1994, pp. 1521-1525
Citations number
34
Categorie Soggetti
Physics, Applied
Journal title
Journal of vacuum science & technology. B, Microelectronics and nanometer structures processing, measurement and phenomena → ACNP
ISSN journal
10711023
Volume
12
Issue
3
Year of publication
1994
Pages
1521 - 1525
Database
ISI
SICI code
1071-1023(1994)12:3<1521:STIODS>2.0.ZU;2-K
Abstract
Scanning tunneling microscopy (STM) observations made on pBR322 DNA ar e compared with methods known to give information on DNA intrinsic cur vature: polyacrylamide gel retardation, electron microscopy and comput er modeling. It is concluded that STM is a powerful method for studyin g DNA structural features. Moreover, it is the only method to reveal s imultaneously nanometric scale detail and long-range information. Use of STM for analyzing fine DNA structural features in regions involved in gene regulation should make an important contribution to genetics.