MACRONUTRIENT SUPPLEMENTS MAY REDUCE BREAST-CANCER RISK - HOW, WHEN AND WHICH

Objective: To examine evidence that specific fibre-associated macronut rients are associated with a decreased breast cancer risk. To review p ossible mechanisms, the age group when dietary intervention might be m ost effective and the choice of a suitable dietary supplement. Design: This review distinguishes specific hormone-metabolic effects of dieta ry composition from those of body mass and fat distribution, in relati on to the age at which they exert major effects on breast cancer risk. Results: Both obesity and a high-fat/low-fibre diet in Western women may be associated with increased estrogen levels which are widely assu med to increase the risk of developing breast cancer. Both obesity and the Western diet are likely to stimulate insulin resistance, leading to increased levels of bioavailable estrogen. The concomitants of hype rinsulinemia may synergize with estrogen in stimulating progression of pre-neoplastic lesions in the breasts of late pre-menopausal women. I ncreased intake of fibre-associated macronutrients may reduce insulin resistance in addition to reducing the circulating levels of estrogen. Conclusions: The effect of dietary intervention on breast cancer risk in Western women may be tested in premenopausal women over the age of 40 y, with evidence of atypical hyperplasia in a breast biopsy. The m ost suitable fibre-associated macronutrient is still problematical but soy protein constituents have been shown to inhibit the growth of rat mammary cancer models and also of human breast cancer cell lines in t he laboratory.