Objective: This study investigated the role of the fat content of milk
on symptoms of lactose intolerance. Design: Subjects recorded intoler
ance symptoms using a visual analogue scale (VAS) following ingestion
of three test milks of varying fat content for a two-day period. Subje
cts/Setting: The subjects were thirty adult volunteers, patients of tw
o Estonian out-patient clinics with diagnosed lactose intolerance. The
study milks were drunk at home or at work. All thirty subjects comple
ted the study protocol. Intervention: Each subject drank, in random or
der, fat-free milk (4.9% lactose), high-fat milk (8% fat, 4.9% lactose
), and a lactose-free and fat-free control milk. They drank 200 mi of
the milk twice a day for two days, one milk type per session, with fiv
e days between sessions. The subjects noted their gastrointestinal sym
ptoms during the test periods and during a 5 d milk-free period at the
beginning of the study. The occurrence and severity of symptoms were
compared. A global measure of the severity of symptoms was defined by
computing the sum of the symptom scores. Results: The sum of symptoms
was higher during all milk periods than during the milk-free period (P
< 0.01). There were no statistically significant differences in the o
ccurrence or severity of symptoms during the fat-free milk period comp
ared with the high-fat milk period. Conclusions: Even a marked differe
nce in the fat content of milk did not affect the symptoms of lactose
intolerance. Consequently, there seems to be no case for recommending
full-fat milk products in the treatment of lactose intolerance.