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Results: 1-23 |
Results: 23
MUTATIONS IN A CONSERVED RESIDUE IN THE INFLUENZA-VIRUS NEURAMINIDASEACTIVE-SITE DECREASES SENSITIVITY TO NEU5AC2EN-DERIVED INHIBITORS
Authors: MCKIMMBRESCHKIN JL SAHASRABUDHE A BLICK TJ MCDONALD M COLMAN PM HART GJ BETHELL RC VARGHESE JN
Citation: Jl. Mckimmbreschkin et al., MUTATIONS IN A CONSERVED RESIDUE IN THE INFLUENZA-VIRUS NEURAMINIDASEACTIVE-SITE DECREASES SENSITIVITY TO NEU5AC2EN-DERIVED INHIBITORS, Journal of virology, 72(3), 1998, pp. 2456-2462
EVIDENCE FOR ZANAMIVIR RESISTANCE IN AN IMMUNOCOMPROMISED CHILD INFECTED WITH INFLUENZA-B VIRUS
Authors: GUBAREVA LV MATROSOVICH MN BRENNER MK BETHELL RC WEBSTER RG
Citation: Lv. Gubareva et al., EVIDENCE FOR ZANAMIVIR RESISTANCE IN AN IMMUNOCOMPROMISED CHILD INFECTED WITH INFLUENZA-B VIRUS, The Journal of infectious diseases, 178(5), 1998, pp. 1257-1262
MUTATIONS AFFECTING THE SENSITIVITY OF THE INFLUENZA-VIRUS NEURAMINIDASE TO ANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID
Authors: GOTO H BETHELL RC KAWAOKA Y
Citation: H. Goto et al., MUTATIONS AFFECTING THE SENSITIVITY OF THE INFLUENZA-VIRUS NEURAMINIDASE TO ANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID, Virology, 238(2), 1997, pp. 265-272
CATALYTIC AND FRAMEWORK MUTATIONS IN THE NEURAMINIDASE ACTIVE-SITE OFINFLUENZA-VIRUSES THAT ARE RESISTANT TO 4-GUANIDINO-NEU5AC2EN
Authors: GUBAREVA LV ROBINSON MJ BETHELL RC WEBSTER RG
Citation: Lv. Gubareva et al., CATALYTIC AND FRAMEWORK MUTATIONS IN THE NEURAMINIDASE ACTIVE-SITE OFINFLUENZA-VIRUSES THAT ARE RESISTANT TO 4-GUANIDINO-NEU5AC2EN, Journal of virology, 71(5), 1997, pp. 3385-3390
NOVEL INHIBITORS OF INFLUENZA SIALIDASES RELATED TO GG167 - STRUCTURE-ACTIVITY, CRYSTALLOGRAPHIC AND MOLECULAR DYNAMIC STUDIES WITH 4H-PYRAN-2-CARBOXYLIC ACID 6-CARBOXAMIDES
Authors: SMITH PW SOLLIS SL HOWES PD CHERRY PC COBLEY KN TAYLOR H WHITTINGTON AR SCICINSKI J BETHELL RC TAYLOR N SKARZYNSKI T CLEASBY A SINGH O WONACOTT A VARGHESE J COLMAN P
Citation: Pw. Smith et al., NOVEL INHIBITORS OF INFLUENZA SIALIDASES RELATED TO GG167 - STRUCTURE-ACTIVITY, CRYSTALLOGRAPHIC AND MOLECULAR DYNAMIC STUDIES WITH 4H-PYRAN-2-CARBOXYLIC ACID 6-CARBOXAMIDES, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2931-2936
NOVEL INHIBITORS OF INFLUENZA SIALIDASE RELATED TO GG167 - SYNTHESIS OF 4-AMINO AND GUANIDINO-4H-PYRAN-2-CARBOXYLIC ACID-6-PROPYLAMIDES - SELECTIVE INHIBITORS OF INFLUENZA-A VIRUS SIALIDASE
Authors: SOLLIS SL SMITH PW HOWES PD CHERRY PC BETHELL RC
Citation: Sl. Sollis et al., NOVEL INHIBITORS OF INFLUENZA SIALIDASE RELATED TO GG167 - SYNTHESIS OF 4-AMINO AND GUANIDINO-4H-PYRAN-2-CARBOXYLIC ACID-6-PROPYLAMIDES - SELECTIVE INHIBITORS OF INFLUENZA-A VIRUS SIALIDASE, Bioorganic & medicinal chemistry letters, 6(15), 1996, pp. 1805-1808
GENERATION AND CHARACTERIZATION OF VARIANTS OF NWS G70C INFLUENZA-VIRUS AFTER IN-VITRO PASSAGE IN 4-AMINO-NEU5AC2EN AND 4-GUANIDINO-NEU5AC2EN/
Authors: MCKIMMBRESCHKIN JL BLICK TJ SAHASRABUDHE A TIONG T MARSHALL D HART GJ BETHELL RC PENN CR
Citation: Jl. Mckimmbreschkin et al., GENERATION AND CHARACTERIZATION OF VARIANTS OF NWS G70C INFLUENZA-VIRUS AFTER IN-VITRO PASSAGE IN 4-AMINO-NEU5AC2EN AND 4-GUANIDINO-NEU5AC2EN/, Antimicrobial agents and chemotherapy, 40(1), 1996, pp. 40-46
PLASMODIUM-FALCIPARUM LACKS SIALIDASE AND TRANS-SIALIDASE ACTIVITY
Authors: CLOUGH B ATILOLA FA HEALY N PEREIRA MEA BETHELL RC PENN CR PASVOL G
Citation: B. Clough et al., PLASMODIUM-FALCIPARUM LACKS SIALIDASE AND TRANS-SIALIDASE ACTIVITY, Parasitology, 112, 1996, pp. 443-449
YDRO-2,4-DIDEOXY-4-GUANIDINO-N-ACETYL-D-NEURAMINIC ACID (4-GUANIDINO-NEU5AC2EN) IS A SLOW-BINDING INHIBITOR OF SIALIDASE FROM BOTH INFLUENZA-A VIRUS AND INFLUENZA-B VIRUS
Authors: HART GJ BETHELL RC
Citation: Gj. Hart et Rc. Bethell, YDRO-2,4-DIDEOXY-4-GUANIDINO-N-ACETYL-D-NEURAMINIC ACID (4-GUANIDINO-NEU5AC2EN) IS A SLOW-BINDING INHIBITOR OF SIALIDASE FROM BOTH INFLUENZA-A VIRUS AND INFLUENZA-B VIRUS, Biochemistry and molecular biology international, 36(4), 1995, pp. 695-703
GENERATION AND CHARACTERIZATION OF AN INFLUENZA-VIRUS NEURAMINIDASE VARIANT WITH DECREASED SENSITIVITY TO THE NEURAMINIDASE-SPECIFIC INHIBITOR 4-GUANIDINO-NEU5AC2EN
Authors: BLICK TJ TIONG T SAHASRABUDHE A VARGHESE JN COLMAN PM HART GJ BETHELL RC MCKIMMBRESCHKIN JL
Citation: Tj. Blick et al., GENERATION AND CHARACTERIZATION OF AN INFLUENZA-VIRUS NEURAMINIDASE VARIANT WITH DECREASED SENSITIVITY TO THE NEURAMINIDASE-SPECIFIC INHIBITOR 4-GUANIDINO-NEU5AC2EN, Virology, 214(2), 1995, pp. 475-484
BENZOPHENONE DERIVATIVES - A NOVEL SERIES OF POTENT AND SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE
Authors: WYATT PG BETHELL RC CAMMACK N CHARON D DODIC N DUMAITRE B EVANS DN GREEN DVS HOPEWELL PL HUMBER DC LAMONT RB ORR DC PLESTED SJ RYAN DM SOLLIS SL STORER R WEINGARTEN GG
Citation: Pg. Wyatt et al., BENZOPHENONE DERIVATIVES - A NOVEL SERIES OF POTENT AND SELECTIVE INHIBITORS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE, Journal of medicinal chemistry, 38(10), 1995, pp. 1657-1665
THE INTRACELLULAR PHOSPHORYLATION OF (-)-2'-DEOXY-3'-THIACYTIDINE (3TC) AND THE INCORPORATION OF 3TC 5'-MONOPHOSPHATE INTO DNA BY HIV-1 REVERSE TRANSCRIPTASE AND HUMAN DNA-POLYMERASE-GAMMA
Authors: GRAY NM MARR CLP PENN CR CAMERON JM BETHELL RC
Citation: Nm. Gray et al., THE INTRACELLULAR PHOSPHORYLATION OF (-)-2'-DEOXY-3'-THIACYTIDINE (3TC) AND THE INCORPORATION OF 3TC 5'-MONOPHOSPHATE INTO DNA BY HIV-1 REVERSE TRANSCRIPTASE AND HUMAN DNA-POLYMERASE-GAMMA, Biochemical pharmacology, 50(7), 1995, pp. 1043-1051
THE KINETICS OF THE ACID-INDUCED CONFORMATIONAL CHANGE OF INFLUENZA-VIRUS HEMAGGLUTININ CAN BE FOLLOWED USING 1,1'-BIS(4-ANILINO-5-NAPHTHALENESULPHONIC ACID)
Authors: BETHELL RC GRAY NM PENN CR
Citation: Rc. Bethell et al., THE KINETICS OF THE ACID-INDUCED CONFORMATIONAL CHANGE OF INFLUENZA-VIRUS HEMAGGLUTININ CAN BE FOLLOWED USING 1,1'-BIS(4-ANILINO-5-NAPHTHALENESULPHONIC ACID), Biochemical and biophysical research communications, 206(1), 1995, pp. 355-361
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED PSEUDOSYMMETRIC INHIBITORS OF HIV-1 PROTEINASE
Authors: HUMBER DC BAMFORD MJ BETHELL RC CAMMACK N ORR DC STORER R WEINGARTEN GG WYATT PG
Citation: Dc. Humber et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED PSEUDOSYMMETRIC INHIBITORS OF HIV-1 PROTEINASE, Antiviral chemistry & chemotherapy, 5(3), 1994, pp. 197-200
SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE DIPHOSPHORYLPHOSPHONATE DERIVATIVES OF (-CIS-9-(4'-HYDROXYCYCLOPENT-2'-ENYL)GUANINE AND (-)-CIS-9-(4'- HYDROXYCYCLOPENT-2'-ENYL)GUANINE())
Authors: MERLO V ROBERTS SM STORER R BETHELL RC
Citation: V. Merlo et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF THE DIPHOSPHORYLPHOSPHONATE DERIVATIVES OF (-CIS-9-(4'-HYDROXYCYCLOPENT-2'-ENYL)GUANINE AND (-)-CIS-9-(4'- HYDROXYCYCLOPENT-2'-ENYL)GUANINE()), Journal of the Chemical Society. Perkin transactions. I, (11), 1994, pp. 1477-1481
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED HIV PROTEINASE-INHIBITORS - HETEROCYCLIC RING-SYSTEMS CONTAINING P-1' AND P-2' SUBSTITUENTS
Authors: KITCHIN J BETHELL RC CAMMACK N DOLAN S EVANS DN HOLMAN S HOLMES DS MCMEEKIN P MO CL NIELAND N ORR DC SAUNDERS J SHENOY BEV STARKEY ID STORER R
Citation: J. Kitchin et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED HIV PROTEINASE-INHIBITORS - HETEROCYCLIC RING-SYSTEMS CONTAINING P-1' AND P-2' SUBSTITUENTS, Journal of medicinal chemistry, 37(22), 1994, pp. 3707-3716
DISCOVERY AND ANALYSIS OF A SERIES OF C-2-SYMMETRICAL HIV-1 PROTEINASE-INHIBITORS DERIVED FROM PENICILLIN
Authors: GRAY NM CAMERON JM CAMMACK N COBLEY KN HOLMES DS HUMBER DC ORR DC PENN CR POTTER R MADAR S WEINGARTEN GG BETHELL RC
Citation: Nm. Gray et al., DISCOVERY AND ANALYSIS OF A SERIES OF C-2-SYMMETRICAL HIV-1 PROTEINASE-INHIBITORS DERIVED FROM PENICILLIN, Analytical biochemistry, 216(1), 1994, pp. 89-96
THE DESIGN AND SYNTHESIS OF NOVEL HYDROXYPROLINE INHIBITORS OF HIV-1 PROTEINASE
Authors: HOLMES DS BETHELL RC HANN MM KITCHIN J STARKEY ID STORER R
Citation: Ds. Holmes et al., THE DESIGN AND SYNTHESIS OF NOVEL HYDROXYPROLINE INHIBITORS OF HIV-1 PROTEINASE, Bioorganic & medicinal chemistry letters, 3(8), 1993, pp. 1485-1491
ANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID IS A HIGHLY EFFECTIVE INHIBITOR BOTH OF THE SIALIDASE (NEURAMINIDASE) AND OF GROWTHOF A WIDE-RANGE OF INFLUENZA-A AND INFLUENZA-B VIRUSES IN-VITRO
Authors: WOODS JM BETHELL RC COATES JAV HEALY N HISCOX SA PEARSON BA RYAN DM TICEHURST J TILLING J WALCOTT SM PENN CR
Citation: Jm. Woods et al., ANIDINO-2,4-DIDEOXY-2,3-DEHYDRO-N-ACETYLNEURAMINIC ACID IS A HIGHLY EFFECTIVE INHIBITOR BOTH OF THE SIALIDASE (NEURAMINIDASE) AND OF GROWTHOF A WIDE-RANGE OF INFLUENZA-A AND INFLUENZA-B VIRUSES IN-VITRO, Antimicrobial agents and chemotherapy, 37(7), 1993, pp. 1473-1479
RATIONAL DESIGN OF POTENT SIALIDASE-BASED INHIBITORS OF INFLUENZA-VIRUS REPLICATION
Authors: VONITZSTEIN M WU WY KOK GB PEGG MS DYASON JC JIN B PHAN TV SMYTHE ML WHITE HF OLIVER SW COLMAN PM VARGHESE JN RYAN DM WOODS JM BETHELL RC HOTHAM VJ CAMERON JM PENN CR
Citation: M. Vonitzstein et al., RATIONAL DESIGN OF POTENT SIALIDASE-BASED INHIBITORS OF INFLUENZA-VIRUS REPLICATION, Nature, 363(6428), 1993, pp. 418-423
SYNTHESIS AND ANTI-HIV-1 ACTIVITY OF A SERIES OF IMIDAZO[1,5-B]PYRIDAZINES
Authors: LIVERMORE DGH BETHELL RC CAMMACK N HANCOCK AP HANN MM GREEN DVS LAMONT RB NOBLE SA ORR DC PAYNE JJ RAMSAY MVJ SHINGLER AH SMITH C STORER R WILLIAMSON C WILLSON T
Citation: Dgh. Livermore et al., SYNTHESIS AND ANTI-HIV-1 ACTIVITY OF A SERIES OF IMIDAZO[1,5-B]PYRIDAZINES, Journal of medicinal chemistry, 36(24), 1993, pp. 3784-3794
A SERIES OF PENICILLIN DERIVED C2-SYMMETRICAL INHIBITORS OF HIV-1 PROTEINASE - SYNTHESIS, MODE OF INTERACTION, AND STRUCTURE-ACTIVITY-RELATIONSHIPS
Authors: HUMBER DC BAMFORD MJ BETHELL RC CAMMACK N COBLEY K EVANS DN GRAY NM HANN MM ORR DC SAUNDERS J SHENOY BEV STORER R WEINGARTEN GG WYATT PG
Citation: Dc. Humber et al., A SERIES OF PENICILLIN DERIVED C2-SYMMETRICAL INHIBITORS OF HIV-1 PROTEINASE - SYNTHESIS, MODE OF INTERACTION, AND STRUCTURE-ACTIVITY-RELATIONSHIPS, Journal of medicinal chemistry, 36(21), 1993, pp. 3120-3128
SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED HIV PROTEINASE-INHIBITORS CONTAINING A STEREOCHEMICALLY UNIQUE PEPTIDE ISOSTERE
Authors: HOLMES DS BETHELL RC CAMMACK N CLEMENS IR KITCHIN J MCMEEKIN P MO CL ORR DC PATEL B PATERNOSTER IL STORER R
Citation: Ds. Holmes et al., SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF PENICILLIN-DERIVED HIV PROTEINASE-INHIBITORS CONTAINING A STEREOCHEMICALLY UNIQUE PEPTIDE ISOSTERE, Journal of medicinal chemistry, 36(21), 1993, pp. 3129-3136
Risultati: 1-23 |