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Results: 1-11 |
Results: 11
Synthetic studies on the pederin family of antitumour agents. Syntheses ofmycalamide B, theopederin D and pederin
Authors: Kocienski, P Narquizian, R Raubo, P Smith, C Farrugia, LJ Muir, K Boyle, FT
Citation: P. Kocienski et al., Synthetic studies on the pederin family of antitumour agents. Syntheses ofmycalamide B, theopederin D and pederin, J CHEM S P1, (15), 2000, pp. 2357-2384
Resistance-modifying agents. 8. Inhibition of O-6-alkylguanine-DNA alkyltransferase by O-6-alkenyl-, O-6-cycloalkenyl-, and O-6-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O-6-(1-cyclopentenylmethyl)guanine
Authors: Griffin, RJ Arris, CE Bleasdale, C Boyle, FT Calvert, AH Curtin, NJ Dalby, C Kanugula, S Lembicz, NK Newell, DR Pegg, AE Golding, BT
Citation: Rj. Griffin et al., Resistance-modifying agents. 8. Inhibition of O-6-alkylguanine-DNA alkyltransferase by O-6-alkenyl-, O-6-cycloalkenyl-, and O-6-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O-6-(1-cyclopentenylmethyl)guanine, J MED CHEM, 43(22), 2000, pp. 4071-4083
Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles
Authors: Arris, CE Boyle, FT Calvert, AH Curtin, NJ Endicott, JA Garman, EF Gibson, AE Golding, BT Grant, S Griffin, RJ Jewsbury, P Johnson, LN Lawrie, AM Newell, DR Noble, MEM Sausville, EA Schultz, R Yu, W
Citation: Ce. Arris et al., Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles, J MED CHEM, 43(15), 2000, pp. 2797-2804
Design and synthesis of cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents
Authors: Bavetsias, V Marriott, JH Melin, C Kimbell, R Matusiak, ZS Boyle, FT Jackman, AL
Citation: V. Bavetsias et al., Design and synthesis of cyclopenta[g]quinazoline-based antifolates as inhibitors of thymidylate synthase and potential antitumor agents, J MED CHEM, 43(10), 2000, pp. 1910-1926
Paradoxical activation of Raf by a novel Raf inhibitor
Authors: Hall-Jackson, CA Eyers, PA Cohen, P Goedert, M Boyle, FT Hewitt, N Plant, H Hedge, P
Citation: Ca. Hall-jackson et al., Paradoxical activation of Raf by a novel Raf inhibitor, CHEM BIOL, 6(8), 1999, pp. 559-568
Chemoenzymatic preparation of the novel antifolate thymidylate synthase inhibitor N-(4-{N-[(6S)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta [g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}-benzoyl)-L-glutamic acid and its glutamyl cleavage product
Authors: Marriott, JH Neidle, S Matusiak, Z Bavetsias, V Jackman, AL Melin, C Boyle, FT
Citation: Jh. Marriott et al., Chemoenzymatic preparation of the novel antifolate thymidylate synthase inhibitor N-(4-{N-[(6S)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta [g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}-benzoyl)-L-glutamic acid and its glutamyl cleavage product, J CHEM S P1, (11), 1999, pp. 1495-1503
A formal synthesis of 18-O-methyl mycalamide B
Authors: Kocienski, PJ Raubo, P Smith, C Boyle, FT
Citation: Pj. Kocienski et al., A formal synthesis of 18-O-methyl mycalamide B, SYNTHESIS-S, (12), 1999, pp. 2087-2095
Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors
Authors: Marsham, PR Wardleworth, JM Boyle, FT Hennequin, LF Kimbell, R Brown, M Jackman, AL
Citation: Pr. Marsham et al., Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors, J MED CHEM, 42(19), 1999, pp. 3809-3820
Raltitrexed (Tomudex (TM)), a highly polyglutamatable antifolate thymidylate synthase inhibitor - Design and preclinical activity
Authors: Hughes, LR Stephens, TC Boyle, FT Jackman, AL
Citation: Lr. Hughes et al., Raltitrexed (Tomudex (TM)), a highly polyglutamatable antifolate thymidylate synthase inhibitor - Design and preclinical activity, CANC DRUG, 1999, pp. 147-165
ZD9331 - Preclinical and clinical studies
Authors: Boyle, FT Stephens, TC Averbuch, SD Jackman, AL
Citation: Ft. Boyle et al., ZD9331 - Preclinical and clinical studies, CANC DRUG, 1999, pp. 243-260
A synthesis of theopederin D and a formal synthesis of pederin
Authors: Kocienski, PJ Narquizian, R Raubo, P Smith, C Boyle, FT
Citation: Pj. Kocienski et al., A synthesis of theopederin D and a formal synthesis of pederin, SYNLETT, (12), 1998, pp. 1432-1434
Risultati: 1-11 |