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Results: 1-25 |
Results: 25
Human beta(3) adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties
Authors: Brockunier, LL Candelore, MR Cascieri, MA Liu, Y Tota, L Wyvratt, MJ Fisher, MH Weber, AE Parmee, ER
Citation: Ll. Brockunier et al., Human beta(3) adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties, BIOORG MED, 11(3), 2001, pp. 379-382
Substituted imidazoles as glucagon receptor antagonists
Authors: Chang, LL Sidler, KL Cascieri, MA de Laszlo, S Koch, G Li, B MacCoss, M Mantlo, N O'Keefe, S Pang, M Rolando, A Hagmann, WK
Citation: Ll. Chang et al., Substituted imidazoles as glucagon receptor antagonists, BIOORG MED, 11(18), 2001, pp. 2549-2553
beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, racial flushing, and reflex tachycardia in anesthetized rhesus monkeys
Authors: Hom, GJ Forrest, MJ Bach, TJ Brady, E Candelore, MR Cascieri, MA Fletcher, DJ Fisher, MH Iliff, SA Mathvink, R Metzger, J Pecore, V Saperstein, R Shih, T Weber, AE Wyvratt, M Zafian, P Macintyre, DE
Citation: Gj. Hom et al., beta(3)-adrenoceptor agonist-induced increases in lipolysis, metabolic rate, racial flushing, and reflex tachycardia in anesthetized rhesus monkeys, J PHARM EXP, 297(1), 2001, pp. 299-307
An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration
Authors: Harrison, T Owens, AP Williams, BJ Swain, CJ Williams, A Carlson, EJ Rycroft, W Tattersall, FD Cascieri, MA Chicchi, GG Sadowski, S Rupniak, NMJ Hargreaves, RJ
Citation: T. Harrison et al., An orally active, water-soluble neurokinin-1 receptor antagonist suitable for both intravenous and oral clinical administration, J MED CHEM, 44(24), 2001, pp. 4296-4299
The chemokine/chemokine-receptor family: potential and progress for therapeutic intervention
Authors: Cascieri, MA Springer, MS
Citation: Ma. Cascieri et Ms. Springer, The chemokine/chemokine-receptor family: potential and progress for therapeutic intervention, CURR OP C B, 4(4), 2000, pp. 420-427
Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta(3) adrenergic receptor agonists
Authors: Parmee, ER Brockunier, LL He, JF Singh, SB Candelore, MR Cascieri, MA Deng, LP Liu, Y Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Er. Parmee et al., Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta(3) adrenergic receptor agonists, BIOORG MED, 10(20), 2000, pp. 2283-2286
Human beta 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides
Authors: Brockunier, LL Parmee, ER Ok, HO Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Ll. Brockunier et al., Human beta 3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides, BIOORG MED, 10(18), 2000, pp. 2111-2114
Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore
Authors: Mathvink, RJ Tolman, JS Chitty, D Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Rj. Mathvink et al., Potent, selective 3-pyridylethanolamine beta(3) adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore, BIOORG MED, 10(17), 2000, pp. 1971-1973
Substituted oxazole benzenesulfonamides as potent human beta(3) adrenergicreceptor agonists
Authors: Ok, HO Reigle, LB Candelore, MR Cascieri, MA Colwell, LF Deng, L Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Strader, CD Tota, L Wang, P Wyvratt, MJ Fisher, MH Weber, AE
Citation: Ho. Ok et al., Substituted oxazole benzenesulfonamides as potent human beta(3) adrenergicreceptor agonists, BIOORG MED, 10(14), 2000, pp. 1531-1534
Discovery of an orally bioavailable alkyl oxadiazole beta(3) adrenergic receptor agonist
Authors: Feng, DQD Biftu, T Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Miller, RR Stearns, RA Strader, CD Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Dqd. Feng et al., Discovery of an orally bioavailable alkyl oxadiazole beta(3) adrenergic receptor agonist, BIOORG MED, 10(13), 2000, pp. 1427-1429
Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta(3) adrenergic receptor agonist antiobesity agents
Authors: Biftu, T Feng, DD Liang, GB Kuo, H Qian, XX Naylor, EM Colandrea, VJ Candelore, MR Cascieri, MA Colwell, LF Forrest, MJ Hom, GJ MacIntyre, DE Stearns, RA Strader, CD Wyvratt, MJ Fisher, MH Weber, AE
Citation: T. Biftu et al., Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta(3) adrenergic receptor agonist antiobesity agents, BIOORG MED, 10(13), 2000, pp. 1431-1434
Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs
Authors: Hale, JJ Mills, SG MacCoss, M Dorn, CP Finke, PE Budhu, RJ Reamer, RA Huskey, SEW Luffer-Atlas, D Dean, BJ McGowan, EM Feeney, WP Chiu, SHL Cascieri, MA Chicchi, GG Kurtz, MM Sadowski, S Ber, E Tattersall, FD Rupniak, NMJ Williams, AR Rycroft, W Hargreaves, R Metzger, JM MacIntyre, DE
Citation: Jj. Hale et al., Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs, J MED CHEM, 43(6), 2000, pp. 1234-1241
Synthesis of a substance P antagonist with a somatostatin scaffold: Factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry
Authors: Liu, J Underwood, DJ Cascieri, MA Rohrer, SP Cantin, LD Chicchi, G Smith, AB Hirschmann, R
Citation: J. Liu et al., Synthesis of a substance P antagonist with a somatostatin scaffold: Factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry, J MED CHEM, 43(21), 2000, pp. 3827-3831
Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide
Authors: Mathvink, RJ Tolman, JS Chitty, D Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Miller, RR Stearns, RA Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Rj. Mathvink et al., Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide, J MED CHEM, 43(21), 2000, pp. 3832-3836
The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both G(alpha i)-coupled and uncoupled states
Authors: Di Salvo, J Koch, GE Johnson, KE Blake, AD Daugherty, BL DeMartino, JA Sirotina-Meisher, A Liu, Y Springer, MS Cascieri, MA Sullivan, KA
Citation: J. Di Salvo et al., The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both G(alpha i)-coupled and uncoupled states, EUR J PHARM, 409(2), 2000, pp. 143-154
L-750355, a human beta 3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey
Authors: Forrest, MJ Hom, G Bach, T Candelore, MR Cascieri, MA Strader, C Tota, L Fisher, MH Szumiloski, J Ok, HO Weber, AE Wyvratt, M Vicario, P Marko, O Deng, LP Cioffe, C Hegarty-Friscino, B MacIntyre, E
Citation: Mj. Forrest et al., L-750355, a human beta 3-adrenoceptor agonist; in vitro pharmacology and profile of activity in vivo in the rhesus monkey, EUR J PHARM, 407(1-2), 2000, pp. 175-181
Generation of mice expressing the human glucagon receptor with a direct replacement vector
Authors: Shiao, LL Cascieri, MA Trumbauer, M Chen, H Sullivan, KA
Citation: Ll. Shiao et al., Generation of mice expressing the human glucagon receptor with a direct replacement vector, TRANSGEN RE, 8(4), 1999, pp. 295-302
L-770,644: A potent and selective human beta(3) adrenergic receptor agonist with improved oral bioavailability
Authors: Shih, TL Candelore, MR Cascieri, MA Chiu, SHL Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Miller, RR Stearns, RA Strader, CD Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Tl. Shih et al., L-770,644: A potent and selective human beta(3) adrenergic receptor agonist with improved oral bioavailability, BIOORG MED, 9(9), 1999, pp. 1251-1254
Potent, orally absorbed glucagon receptor antagonists
Authors: de Laszlo, SE Hacker, C Li, B Kim, D MacCoss, M Mantlo, N Pivnichny, JV Colwell, L Koch, GE Cascieri, MA Hagmann, WK
Citation: Se. De Laszlo et al., Potent, orally absorbed glucagon receptor antagonists, BIOORG MED, 9(5), 1999, pp. 641-646
Human beta(3) adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides
Authors: Parmee, ER Naylor, EM Perkins, L Colandrea, VJ Ok, HO Candelore, MR Cascieri, MA Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Miller, RR Stearns, RA Strader, CD Tota, L Wyvratt, MJ Fisher, MH Weber, AE
Citation: Er. Parmee et al., Human beta(3) adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides, BIOORG MED, 9(5), 1999, pp. 749-754
Human beta(3) adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides
Authors: Naylor, EM Parmee, ER Colandrea, VJ Perkins, L Brockunier, L Candelore, MR Cascieri, MA Colwell, LF Deng, LP Feeney, WP Forrest, MJ Hom, GJ MacIntyre, DE Strader, CD Tota, L Wang, PR Wyvratt, MJ Fisher, MH Weber, AE
Citation: Em. Naylor et al., Human beta(3) adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides, BIOORG MED, 9(5), 1999, pp. 755-758
Potent, selective human beta(3) adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore
Authors: Mathvink, RJ Barritta, AM Candelore, MR Cascieri, MA Deng, LP Tota, L Strader, CD Wyvratt, MJ Fisher, MH Weber, AE
Citation: Rj. Mathvink et al., Potent, selective human beta(3) adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore, BIOORG MED, 9(13), 1999, pp. 1869-1874
Receptor for motilin identified in the human gastrointestinal system
Authors: Feighner, SD Tan, CP McKee, KK Palyha, OC Hreniuk, DL Pong, SS Austin, CP Figueroa, D MacNeil, D Cascieri, MA Nargund, R Bakshi, R Abramovitz, M Stocco, R Kargman, S O'Neill, G Van der Ploeg, LHT Evans, J Patchett, AA Smith, RG Howard, AD
Citation: Sd. Feighner et al., Receptor for motilin identified in the human gastrointestinal system, SCIENCE, 284(5423), 1999, pp. 2184-2188
Potent and selective human beta(3)-adrenergic receptor antagonists
Authors: Candelore, MR Deng, LP Tota, L Guan, XM Amend, A Liu, Y Newbold, R Cascieri, MA Weber, AE
Citation: Mr. Candelore et al., Potent and selective human beta(3)-adrenergic receptor antagonists, J PHARM EXP, 290(2), 1999, pp. 649-655
Characterization of a novel, non-peptidyl antagonist of the human glucagonreceptor
Authors: Cascieri, MA Koch, GE Ber, E Sadowski, SJ Louizides, D de Laszlo, SE Hacker, C Hagmann, WK MacCoss, M Chicchi, GG Vicario, PP
Citation: Ma. Cascieri et al., Characterization of a novel, non-peptidyl antagonist of the human glucagonreceptor, J BIOL CHEM, 274(13), 1999, pp. 8694-8697
Risultati: 1-25 |