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Results: 26-50/115
ANILINE MUSTARD ANALOGS OF THE DNA-INTERCALATING AGENT AMSACRINE - DNA INTERACTION AND BIOLOGICAL-ACTIVITY
Authors: FAN JY VALU KK WOODGATE PD BAGULEY BC DENNY WA
Citation: Jy. Fan et al., ANILINE MUSTARD ANALOGS OF THE DNA-INTERCALATING AGENT AMSACRINE - DNA INTERACTION AND BIOLOGICAL-ACTIVITY, Anti-cancer drug design, 12(3), 1997, pp. 181-203
BIS-TROPOLONATO DERIVATIVES OF COBALT(III) COMPLEXES OF BIDENTATE ALIPHATIC NITROGEN MUSTARDS AS POTENTIAL HYPOXIA-SELECTIVE CYTOTOXINS
Authors: WARE DC PALMER HR BROTHERS PJ RICKARD CEF WILSON WR DENNY WA
Citation: Dc. Ware et al., BIS-TROPOLONATO DERIVATIVES OF COBALT(III) COMPLEXES OF BIDENTATE ALIPHATIC NITROGEN MUSTARDS AS POTENTIAL HYPOXIA-SELECTIVE CYTOTOXINS, Journal of inorganic biochemistry, 68(3), 1997, pp. 215-224
']BIS(3-METHYL-2,4-PENTANEDIONATO-O,O')COBALT(III) PERCHLORATE - A POTENTIAL HYPOXIA-SELECTIVE ANTICANCER AGENT
Authors: WARE DC DENNY WA CLARK GR
Citation: Dc. Ware et al., ']BIS(3-METHYL-2,4-PENTANEDIONATO-O,O')COBALT(III) PERCHLORATE - A POTENTIAL HYPOXIA-SELECTIVE ANTICANCER AGENT, Acta crystallographica. Section C, Crystal structure communications, 53, 1997, pp. 1058-1059
A NEW SYNTHESIS OF CARMETHIZOLE AND RELATED NITROGEN ANALOGS
Authors: HAY MP DENNY WA
Citation: Mp. Hay et Wa. Denny, A NEW SYNTHESIS OF CARMETHIZOLE AND RELATED NITROGEN ANALOGS, Tetrahedron letters, 38(48), 1997, pp. 8425-8428
A NEW SYNTHESIS OF SUBSTITUTED ACRIDINE-4-CARBOXYLIC ACIDS AND THE ANTICANCER DRUG N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE (DACA)
Authors: GAMAGE SA SPICER JA REWCASTLE GW DENNY WA
Citation: Sa. Gamage et al., A NEW SYNTHESIS OF SUBSTITUTED ACRIDINE-4-CARBOXYLIC ACIDS AND THE ANTICANCER DRUG N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE (DACA), Tetrahedron letters, 38(4), 1997, pp. 699-702
COPPER-DEPENDENT OXIDATIVE AND TOPOISOMERASE II-MEDIATED DNA CLEAVAGEBY A NETROPSIN 4'-(9-ACRIDINYLAMINO)METHANESULFON-M-ANISIDIDE COMBILEXIN/
Authors: HENICHART JP WARING MJ RIOU JF DENNY WA BAILLY C
Citation: Jp. Henichart et al., COPPER-DEPENDENT OXIDATIVE AND TOPOISOMERASE II-MEDIATED DNA CLEAVAGEBY A NETROPSIN 4'-(9-ACRIDINYLAMINO)METHANESULFON-M-ANISIDIDE COMBILEXIN/, Molecular pharmacology, 51(3), 1997, pp. 448-461
HYPOXIA-SELECTIVE ANTITUMOR AGENTS .15. MODIFICATION OF RATE OF NITROREDUCTION AND EXTENT OF LYSOSOMAL UPTAKE BY POLYSUBSTITUTION OF 4-(ALKYLAMINO)-5-NITROQUINOLINE BIOREDUCTIVE DRUGS
Authors: SIIM BG ATWELL GJ ANDERSON RF WARDMAN P PULLEN SM WILSON WR DENNY WA
Citation: Bg. Siim et al., HYPOXIA-SELECTIVE ANTITUMOR AGENTS .15. MODIFICATION OF RATE OF NITROREDUCTION AND EXTENT OF LYSOSOMAL UPTAKE BY POLYSUBSTITUTION OF 4-(ALKYLAMINO)-5-NITROQUINOLINE BIOREDUCTIVE DRUGS, Journal of medicinal chemistry, 40(9), 1997, pp. 1381-1390
MUSTARD PRODRUGS FOR ACTIVATION BY ESCHERICHIA-COLI NITROREDUCTASE INGENE-DIRECTED ENZYME PRODRUG THERAPY
Authors: FRIEDLOS F DENNY WA PALMER BD SPRINGER CJ
Citation: F. Friedlos et al., MUSTARD PRODRUGS FOR ACTIVATION BY ESCHERICHIA-COLI NITROREDUCTASE INGENE-DIRECTED ENZYME PRODRUG THERAPY, Journal of medicinal chemistry, 40(8), 1997, pp. 1270-1275
TYROSINE KINASE INHIBITORS .6. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DISELENOBIS(1H-INDOLES) FOR INHIBITION OF PROTEIN-TYROSINE KINASES AND COMPARATIVE IN-VITRO AND IN-VIVO STUDIES AGAINST SELECTED SULFUR CONGENERS
Authors: SHOWALTER HDH SERCEL AD LEJA BM WOLFANGEL CD AMBROSO LA ELLIOTT WL FRY DW KRAKER AJ HOWARD CT LU GH MOORE CW NELSON JM ROBERTS BJ VINCENT PW DENNY WA THOMPSON AM
Citation: Hdh. Showalter et al., TYROSINE KINASE INHIBITORS .6. STRUCTURE-ACTIVITY-RELATIONSHIPS AMONGN-SUBSTITUTED AND 3-SUBSTITUTED 2,2'-DISELENOBIS(1H-INDOLES) FOR INHIBITION OF PROTEIN-TYROSINE KINASES AND COMPARATIVE IN-VITRO AND IN-VIVO STUDIES AGAINST SELECTED SULFUR CONGENERS, Journal of medicinal chemistry, 40(4), 1997, pp. 413-426
TYROSINE KINASE INHIBITORS .13. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR SOLUBLE 7-SUBSTITUTED 4-[(3-BROMOPHENYL)AMINO]PYRIDO[4,3-D]PYRIMIDINESDESIGNED AS INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: THOMPSON AM MURRAY DK ELLIOTT WL FRY DW NELSON JA SHOWALTER HDH ROBERTS BJ VINCENT PW DENNY WA
Citation: Am. Thompson et al., TYROSINE KINASE INHIBITORS .13. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR SOLUBLE 7-SUBSTITUTED 4-[(3-BROMOPHENYL)AMINO]PYRIDO[4,3-D]PYRIMIDINESDESIGNED AS INHIBITORS OF THE TYROSINE KINASE-ACTIVITY OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 40(24), 1997, pp. 3915-3925
STRUCTURE-ACTIVITY-RELATIONSHIPS FOR THE ANTILEISHMANIAL AND ANTITRYPANOSOMAL ACTIVITIES OF 1'-SUBSTITUTED 9-ANILINOACRIDINES
Authors: GAMAGE SA FIGGITT DP WOJCIK SJ RALPH RK RANSIJN A MAUEL J YARDLEY V SNOWDON D CROFT SL DENNY WA
Citation: Sa. Gamage et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR THE ANTILEISHMANIAL AND ANTITRYPANOSOMAL ACTIVITIES OF 1'-SUBSTITUTED 9-ANILINOACRIDINES, Journal of medicinal chemistry, 40(16), 1997, pp. 2634-2642
SYNTHESIS AND ANTITUMOR PROPERTIES OF N-[2-(DIMETHYLAMINO)ETHYL]CARBOXAMIDE DERIVATIVES OF FUSED TETRACYCLIC QUINOLINES AND QUINOXALINES - A NEW CLASS OF PUTATIVE TOPOISOMERASE INHIBITORS
Authors: DEADY LW KAYE AJ FINLAY GJ BAGULEY BC DENNY WA
Citation: Lw. Deady et al., SYNTHESIS AND ANTITUMOR PROPERTIES OF N-[2-(DIMETHYLAMINO)ETHYL]CARBOXAMIDE DERIVATIVES OF FUSED TETRACYCLIC QUINOLINES AND QUINOXALINES - A NEW CLASS OF PUTATIVE TOPOISOMERASE INHIBITORS, Journal of medicinal chemistry, 40(13), 1997, pp. 2040-2046
TYROSINE KINASE INHIBITORS .12. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 6-SUBSTITUTED 4-(PHENYLAMINO)PYRIMIDO[5,4-D]PYRIMIDINES DESIGNED AS INHIBITORS OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR
Authors: REWCASTLE GW BRIDGES AJ FRY DW RUBIN JR DENNY WA
Citation: Gw. Rewcastle et al., TYROSINE KINASE INHIBITORS .12. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 6-SUBSTITUTED 4-(PHENYLAMINO)PYRIMIDO[5,4-D]PYRIMIDINES DESIGNED AS INHIBITORS OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR, Journal of medicinal chemistry, 40(12), 1997, pp. 1820-1826
STRUCTURE-ACTIVITY-RELATIONSHIPS FOR ACRIDINE-SUBSTITUTED ANALOGS OF THE MIXED TOPOISOMERASE I II INHIBITOR N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE/
Authors: SPICER JA GAMAGE SA ATWELL GJ FINLAY GJ BAGULEY BC DENNY WA
Citation: Ja. Spicer et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR ACRIDINE-SUBSTITUTED ANALOGS OF THE MIXED TOPOISOMERASE I II INHIBITOR N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE/, Journal of medicinal chemistry, 40(12), 1997, pp. 1919-1929
TYROSINE KINASE INHIBITORS .11. SOLUBLE ANALOGS OF PYRROLOQUINAZOLINES AND PYRAZOLOQUINAZOLINES AS EPIDERMAL GROWTH-FACTOR RECEPTOR INHIBITORS - SYNTHESIS, BIOLOGICAL EVALUATION, AND MODELING OF THE MODE OF BINDING
Authors: PALMER BD TRUMPPKALLMEYER S FRY DW NELSON JM SHOWALTER HDH DENNY WA
Citation: Bd. Palmer et al., TYROSINE KINASE INHIBITORS .11. SOLUBLE ANALOGS OF PYRROLOQUINAZOLINES AND PYRAZOLOQUINAZOLINES AS EPIDERMAL GROWTH-FACTOR RECEPTOR INHIBITORS - SYNTHESIS, BIOLOGICAL EVALUATION, AND MODELING OF THE MODE OF BINDING, Journal of medicinal chemistry, 40(10), 1997, pp. 1519-1529
MONODENTATE AND BIDENTATE COORDINATION OF N,N-DIALKYLATED 1,3-PROPANEDIAMINES TO COBALT(III) - A STRUCTURAL AND SPECTROSCOPIC STUDY
Authors: CRAIG PR CLARK GR PALMER BD BROTHERS PJ DENNY WA WARE DC
Citation: Pr. Craig et al., MONODENTATE AND BIDENTATE COORDINATION OF N,N-DIALKYLATED 1,3-PROPANEDIAMINES TO COBALT(III) - A STRUCTURAL AND SPECTROSCOPIC STUDY, Inorganica Chimica Acta, 260(1), 1997, pp. 43-52
STUDIES ON THE METABOLISM OF THE NOVEL ANTITUMOR AGENT 1]N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE IN RATS AND HUMANS PRIOR TO PHASE-I CLINICAL-TRIALS
Authors: OSMAN S LUTHRA SK BRADY F HUME SP BROWN G HARTE RJA MATTHEWS JC DENNY WA BAGULEY BC JONES T PRICE PM
Citation: S. Osman et al., STUDIES ON THE METABOLISM OF THE NOVEL ANTITUMOR AGENT 1]N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE IN RATS AND HUMANS PRIOR TO PHASE-I CLINICAL-TRIALS, Cancer research, 57(11), 1997, pp. 2172-2180
AN EXPERIMENTAL AND MATHEMATICAL-MODEL FOR THE EXTRAVASCULAR TRANSPORT OF A DNA INTERCALATOR IN TUMORS
Authors: HICKS KO OHMS SJ VANZIJL PL DENNY WA HUNTER PJ WILSON WR
Citation: Ko. Hicks et al., AN EXPERIMENTAL AND MATHEMATICAL-MODEL FOR THE EXTRAVASCULAR TRANSPORT OF A DNA INTERCALATOR IN TUMORS, British Journal of Cancer, 76(7), 1997, pp. 894-903
BIOCHEMICAL AND ANTIPROLIFERATIVE PROPERTIES OF 4-[AR(ALK)YLAMINO]PYRIDOPYRIMIDINES, A NEW CHEMICAL CLASS OF POTENT AND SPECIFIC EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITOR
Authors: FRY DW NELSON JM SLINTAK V KELLER PR REWCASTLE GW DENNY WA ZHOU HR BRIDGES AJ
Citation: Dw. Fry et al., BIOCHEMICAL AND ANTIPROLIFERATIVE PROPERTIES OF 4-[AR(ALK)YLAMINO]PYRIDOPYRIMIDINES, A NEW CHEMICAL CLASS OF POTENT AND SPECIFIC EPIDERMAL GROWTH-FACTOR RECEPTOR TYROSINE KINASE INHIBITOR, Biochemical pharmacology, 54(8), 1997, pp. 877-887
NITROGEN AND SULFUR ANALOGS OF THE SECO-CO ALKYLATING AGENT - SYNTHESIS AND CYTOTOXICITY
Authors: TERCEL M DENNY WA WILSON WR
Citation: M. Tercel et al., NITROGEN AND SULFUR ANALOGS OF THE SECO-CO ALKYLATING AGENT - SYNTHESIS AND CYTOTOXICITY, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2735-2740
A NOVEL NITROSUBSTITUTED SECO-CI - APPLICATION AS A REDUCTIVELY ACTIVATED ADEPT PRODRUG
Authors: TERCEL M DENNY WA WILSON WR
Citation: M. Tercel et al., A NOVEL NITROSUBSTITUTED SECO-CI - APPLICATION AS A REDUCTIVELY ACTIVATED ADEPT PRODRUG, Bioorganic & medicinal chemistry letters, 6(22), 1996, pp. 2741-2744
STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 4-ANILINOQUINAZOLINES AS POTENT INHIBITORS AT THE ATP BINDING-SITE OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN-VITRO
Authors: DENNY WA REWCASTLE GW BRIDGES AJ FRY DW KRAKER AJ
Citation: Wa. Denny et al., STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 4-ANILINOQUINAZOLINES AS POTENT INHIBITORS AT THE ATP BINDING-SITE OF THE EPIDERMAL GROWTH-FACTOR RECEPTOR IN-VITRO, Clinical and experimental pharmacology and physiology, 23(5), 1996, pp. 424-427
SYNTHESIS OF 6-SUBSTITUTED PYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONES VIA DIRECTED LITHIATION OF 2-SUBSTITUTED 5-AMINOPYRIDINE DERIVATIVES
Authors: REWCASTLE GW DENNY WA WINTERS RT COLBRY NL SHOWALTER HDH
Citation: Gw. Rewcastle et al., SYNTHESIS OF 6-SUBSTITUTED PYRIDO[3,4-D]PYRIMIDIN-4(3H)-ONES VIA DIRECTED LITHIATION OF 2-SUBSTITUTED 5-AMINOPYRIDINE DERIVATIVES, Journal of the Chemical Society. Perkin transactions. I, (18), 1996, pp. 2221-2226
MOLECULAR-ORIGINS OF SELECTIVITY IN THE INTERACTION OF AMSACRINE-4-CARBOXAMIDE WITH GC-RICH SEQUENCES IN DNA
Authors: BAILLY C DENNY WA WARING MJ
Citation: C. Bailly et al., MOLECULAR-ORIGINS OF SELECTIVITY IN THE INTERACTION OF AMSACRINE-4-CARBOXAMIDE WITH GC-RICH SEQUENCES IN DNA, Anti-cancer drug design, 11(8), 1996, pp. 611-624
SYNTHESIS AND EVALUATION OF 4-SUBSTITUTED ANALOGS OF 5-[N,N-BIS(2-CHLOROETHYL)AMINO]2-NITROBENZAMIDE AS BIOREDUCTIVELY ACTIVATED PRODRUGS USING AN ESCHERICHIA-COLI NITROREDUCTASE
Authors: ATWELL GJ BOYD M PALMER BD ANDERSON RF PULLEN SM WILSON WR DENNY WA
Citation: Gj. Atwell et al., SYNTHESIS AND EVALUATION OF 4-SUBSTITUTED ANALOGS OF 5-[N,N-BIS(2-CHLOROETHYL)AMINO]2-NITROBENZAMIDE AS BIOREDUCTIVELY ACTIVATED PRODRUGS USING AN ESCHERICHIA-COLI NITROREDUCTASE, Anti-cancer drug design, 11(7), 1996, pp. 553-567
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