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Results: 1-7 |
Results: 7
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core
Authors: Fevig, JM Pinto, DJ Han, Q Quan, ML Pruitt, JR Jacobson, IC Galemmo, RA Wang, SA Orwat, MJ Bostrom, LL Knabb, RM Wong, PC Lam, PYS Wexler, RR
Citation: Jm. Fevig et al., Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core, BIOORG MED, 11(5), 2001, pp. 641-645
Discovery of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2 '- (methylsulfonyl)-[1,1 '-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa
Authors: Pinto, DJP Orwat, MJ Wang, SG Fevig, JM Quan, ML Amparo, E Cacciola, J Rossi, KA Alexander, RS Smallwood, AM Luettgen, JM Liang, L Aungst, BJ Wright, MR Knabb, RM Wong, PC Wexler, RR Lam, PYS
Citation: Djp. Pinto et al., Discovery of 1-[3-(aminomethyl)phenyl]-N-[3-fluoro-2 '- (methylsulfonyl)-[1,1 '-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa, J MED CHEM, 44(4), 2001, pp. 566-578
Synthesis and activity studies of conformationally restricted alpha-ketoamide factor Xa inhibitors
Authors: Cacciola, J Fevig, JM Stouten, PFW Alexander, RS Knabb, RM Wexler, RR
Citation: J. Cacciola et al., Synthesis and activity studies of conformationally restricted alpha-ketoamide factor Xa inhibitors, BIOORG MED, 10(11), 2000, pp. 1253-1256
Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa
Authors: Fevig, JM Buriak, J Stouten, PFW Knabb, RM Lam, GN Wong, PC Wexler, RR
Citation: Jm. Fevig et al., Preparation of pyrrolidine and isoxazolidine benzamidines as potent inhibitors of coagulation factor Xa, BIOORG MED, 9(8), 1999, pp. 1195-1200
Anticoagulants: Thrombin and factor Xa inhibitors
Authors: Fevig, JM Wexler, RR
Citation: Jm. Fevig et Rr. Wexler, Anticoagulants: Thrombin and factor Xa inhibitors, ANNU REP M, 34, 1999, pp. 81-100
Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa
Authors: Fevig, JM Cacciola, J Alexander, RS Knabb, RM Lam, GN Wong, PC Wexler, RR
Citation: Jm. Fevig et al., Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa, BIOORG MED, 8(22), 1998, pp. 3143-3148
Biochemical and crystallographic characterization of homologous non-peptidic thrombin inhibitors having alternate binding
Authors: Strickland, CL Fevig, JM Galemmo, RA Wells, BL Kettner, CA Weber, PC
Citation: Cl. Strickland et al., Biochemical and crystallographic characterization of homologous non-peptidic thrombin inhibitors having alternate binding, ACT CRYST D, 54, 1998, pp. 1207-1215
Risultati: 1-7 |