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Results: 1-10 |
Results: 10
1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: A novel series of thrombin inhibitors
Authors: Takeuchi, K Bastian, JA Gifford-Moore, DS Harper, RW Miller, SC Mullaney, JT Sall, DJ Smith, GF Zhang, MS Fisher, MJ
Citation: K. Takeuchi et al., 1,2-disubstituted indole, azaindole and benzimidazole derivatives possessing amine moiety: A novel series of thrombin inhibitors, BIOORG MED, 10(20), 2000, pp. 2347-2351
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues
Authors: Takeuchi, K Kohn, TJ Harper, RW Lin, HS Gifford-Moore, DS Richett, ME Sall, DJ Smith, GF Zhang, MS
Citation: K. Takeuchi et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues, BIOORG MED, 10(11), 2000, pp. 1199-1202
Structure-based design of potent, amidine-derived inhibitors of factor Xa:Evaluation of selectivity, anticoagulant activity, and antithrombotic activity
Authors: Wiley, MR Weir, LC Briggs, S Bryan, NA Buben, J Campbell, C Chirgadze, NY Conrad, RC Craft, TJ Ficorilli, JV Franciskovich, JB Froelich, LL Gifford-Moore, DS Goodson, T Herron, DK Klimkowski, VJ Kurz, KD Kyle, JA Masters, JJ Ratz, AM Milot, G Shuman, RT Smith, T Smith, GF Tebbe, AL Tinsley, JM Towner, RD Wilson, A Yee, YK
Citation: Mr. Wiley et al., Structure-based design of potent, amidine-derived inhibitors of factor Xa:Evaluation of selectivity, anticoagulant activity, and antithrombotic activity, J MED CHEM, 43(5), 2000, pp. 883-899
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives
Authors: Sall, DJ Bailey, DL Bastian, JA Buben, JA Chirgadze, NY Clemens-Smith, AC Denney, ML Fisher, MJ Giera, DD Gifford-Moore, DS Harper, RW Johnson, LM Klimkowski, VJ Kohn, TJ Lin, HS McCowan, JR Palkowitz, AD Richett, ME Smith, GF Snyder, DW Takeuchi, K Toth, JE Zhang, MS
Citation: Dj. Sall et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 5. Potency, efficacy, and pharmacokinetic properties of modified C-3 side chain derivatives, J MED CHEM, 43(4), 2000, pp. 649-663
Non-amidine-containing 1,2-dibenzamidobenzene inhibitors of human factor Xa with potent anticoagulant and antithrombotic activity
Authors: Masters, JJ Franciskovich, JB Tinsley, JM Campbell, C Campbell, JB Craft, TJ Froelich, LL Gifford-Moore, DS Hay, LA Herron, DK Klimkowski, VJ Kurz, KD Metz, JT Ratz, AM Shuman, RT Smith, GF Smith, T Towner, RD Wiley, MR Wilson, A Yee, YK
Citation: Jj. Masters et al., Non-amidine-containing 1,2-dibenzamidobenzene inhibitors of human factor Xa with potent anticoagulant and antithrombotic activity, J MED CHEM, 43(11), 2000, pp. 2087-2092
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restrictedC3-side chain of hydroxybenzo[b]thiophenes
Authors: Takeuchi, K Kohn, TJ Sall, DJ Denney, ML McCowan, JR Smith, GF Gifford-Moore, DS
Citation: K. Takeuchi et al., Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 4. SAR studies on the conformationally restrictedC3-side chain of hydroxybenzo[b]thiophenes, BIOORG MED, 9(5), 1999, pp. 759-764
Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of invivo efficacy
Authors: Zhang, MS Bailey, DL Bastian, JA Briggs, SL Chirgadze, NY Clawson, DK Denney, ML Gifford-Moore, DS Harper, RW Johnson, LM Klimkowski, VJ Kohn, TJ Lin, HS McCowan, JR Richett, ME Sall, DJ Smith, AJ Smith, GF Snyder, DW Takeuchi, K Utterback, BG Yan, SCB
Citation: Ms. Zhang et al., Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of invivo efficacy, BIOORG MED, 9(5), 1999, pp. 775-780
Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain
Authors: Bastian, JA Chirgadze, N Denney, ML Gifford-Moore, DS Sall, DJ Smith, GF Wikel, JH
Citation: Ja. Bastian et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain, BIOORG MED, 9(3), 1999, pp. 363-368
The design of potent, selective, non-covalent, peptide thrombin inhibitorsutilizing imidazole as a S1 binding element
Authors: Wiley, MR Weir, LC Briggs, SI Chirgadze, NY Clawson, D Gifford-Moore, DS Schacht, AL Smith, GF Vasudevan, V Zornes, LL Klimkowski, VJ
Citation: Mr. Wiley et al., The design of potent, selective, non-covalent, peptide thrombin inhibitorsutilizing imidazole as a S1 binding element, BIOORG MED, 9(18), 1999, pp. 2767-2772
Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors
Authors: Johnson, MG Bronson, DD Gillespie, JE Gifford-Moore, DS Kalter, K Lynch, MP McCowan, JR Redick, CC Sall, DJ Smith, GF Foglesong, RJ
Citation: Mg. Johnson et al., Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors, TETRAHEDRON, 55(39), 1999, pp. 11641-11652
Risultati: 1-10 |