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Results: 1-22 |
Results: 22
NOVEL INHIBITORS OF BACTERIAL 2-COMPONENT SYSTEMS WITH GRAM-POSITIVE ANTIBACTERIAL ACTIVITY - PHARMACOPHORE IDENTIFICATION BASED ON THE SCREENING HIT CLOSANTEL
Authors: HLASTA DJ DEMERS JP FOLENO BD FRAGASPANO SA GUAN JH HILLIARD JJ MACIELAG MJ OHEMENG KA SHEPPARD CM SUI ZH WEBB GC WEIDNERWELLS MA WERBLOOD H BARRETT JF
Citation: Dj. Hlasta et al., NOVEL INHIBITORS OF BACTERIAL 2-COMPONENT SYSTEMS WITH GRAM-POSITIVE ANTIBACTERIAL ACTIVITY - PHARMACOPHORE IDENTIFICATION BASED ON THE SCREENING HIT CLOSANTEL, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1923-1928
SAR STUDIES OF DIARYLTRIAZOLES AGAINST BACTERIAL 2-COMPONENT REGULATORY SYSTEMS AND THEIR ANTIBACTERIAL ACTIVITIES
Authors: SUI ZH GUAN JH HLASTA DJ MACIELAG MJ FOLENO BD GOLDSCHMIDT RM LOELOFF MJ WEBB GC BARRETT JF
Citation: Zh. Sui et al., SAR STUDIES OF DIARYLTRIAZOLES AGAINST BACTERIAL 2-COMPONENT REGULATORY SYSTEMS AND THEIR ANTIBACTERIAL ACTIVITIES, Bioorganic & medicinal chemistry letters, 8(14), 1998, pp. 1929-1934
THE REGIOSELECTIVE ACYLATION REACTIONS OF IMIDAZOPYRIDINES
Authors: HLASTA DJ SILBERNAGEL MJ
Citation: Dj. Hlasta et Mj. Silbernagel, THE REGIOSELECTIVE ACYLATION REACTIONS OF IMIDAZOPYRIDINES, Heterocycles, 48(5), 1998, pp. 1015-1022
ANTIBACTERIAL AGENTS THAT INHIBIT 2-COMPONENT SIGNAL-TRANSDUCTION SYSTEMS
Authors: BARRETT JF GOLDSCHMIDT RM LAWRENCE LE FOLENO B CHEN R DEMERS JP JOHNSON S KANOJIA R FERNANDEZ J BERNSTEIN J LICATA L DONETZ A HUANG S HLASTA DJ MACIELAG MJ OHEMENG K FRECHETTE R FROSCO MB KLAUBERT DH WHITELEY JM WANG L HOCH JA
Citation: Jf. Barrett et al., ANTIBACTERIAL AGENTS THAT INHIBIT 2-COMPONENT SIGNAL-TRANSDUCTION SYSTEMS, Proceedings of the National Academy of Sciences of the United Statesof America, 95(9), 1998, pp. 5317-5322
SUBSTITUTED SALICYLANILIDES AS INHIBITORS OF 2-COMPONENT REGULATORY SYSTEMS IN BACTERIA
Authors: MACIELAG MJ DEMERS JP FRAGASPANO SA HLASTA DJ JOHNSON SG KANOJIA RM RUSSEL RK SUI ZH WEIDNERWELLS MA WERBLOOD H FOLENO BD GOLDSCHMIDT RM LOELOFF MJ WEBB GC BARRETT JF
Citation: Mj. Macielag et al., SUBSTITUTED SALICYLANILIDES AS INHIBITORS OF 2-COMPONENT REGULATORY SYSTEMS IN BACTERIA, Journal of medicinal chemistry, 41(16), 1998, pp. 2939-2945
IMIDAZOTRIAZINONE INHIBITORS OF THE CA2-CALMODULIN SENSITIVE PHOSPHODIESTERASE (PDE-I)()
Authors: HLASTA DJ BODE DC COURT JJ DESAI RC PAGANI ED SILVER PJ
Citation: Dj. Hlasta et al., IMIDAZOTRIAZINONE INHIBITORS OF THE CA2-CALMODULIN SENSITIVE PHOSPHODIESTERASE (PDE-I)(), Bioorganic & medicinal chemistry letters, 7(1), 1997, pp. 89-94
A COMPARATIVE SAR AND COMPUTER MODELING STUDY OF BENZISOTHIAZOLONE, MECHANISM-BASED INHIBITORS WITH PORCINE PANCREATIC AND HUMAN-LEUKOCYTE ELASTASE
Authors: HLASTA DJ COURT JJ DESAI RC TALOMIE TG SHEN J DUNLAP RP FRANKE CA MURA AJ
Citation: Dj. Hlasta et al., A COMPARATIVE SAR AND COMPUTER MODELING STUDY OF BENZISOTHIAZOLONE, MECHANISM-BASED INHIBITORS WITH PORCINE PANCREATIC AND HUMAN-LEUKOCYTE ELASTASE, Bioorganic & medicinal chemistry letters, 6(24), 1996, pp. 2941-2946
ORTHO VERSUS ADJACENT-BENZYLIC DIRECTED LITHIATIONS OF SUBSTITUTED N,N-DIETHYLBENZAMIDES
Authors: COURT JJ HLASTA DJ
Citation: Jj. Court et Dj. Hlasta, ORTHO VERSUS ADJACENT-BENZYLIC DIRECTED LITHIATIONS OF SUBSTITUTED N,N-DIETHYLBENZAMIDES, Tetrahedron letters, 37(9), 1996, pp. 1335-1338
THE DESIGN OF POTENT AND STABLE BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
Authors: HLASTA DJ BELL MR COURT JJ CUNDY KC DESAI RC FERGUSON EW GORDON RJ KUMAR V MAYCOCK AL SUBRAMANYAM C
Citation: Dj. Hlasta et al., THE DESIGN OF POTENT AND STABLE BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, Bioorganic & medicinal chemistry letters, 5(4), 1995, pp. 331-336
ALKOXY-SUBSTITUTED BENZISOTHIAZOLONE (BIT) DERIVATIVES - POTENT INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
Authors: DESAI RC DUNLAP RP FARRELL RP FERGUSON E FRANKE CA GORDON R HLASTA DJ TALOMIE TG
Citation: Rc. Desai et al., ALKOXY-SUBSTITUTED BENZISOTHIAZOLONE (BIT) DERIVATIVES - POTENT INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, Bioorganic & medicinal chemistry letters, 5(2), 1995, pp. 105-109
A NOVEL AND PRACTICAL METHOD FOR THE N-BROMOMETHYLATION OF IMIDES ANDISOTHIAZOLONE 1,1-DIOXIDES
Authors: COURT JJ LESSEN TA HLASTA DJ
Citation: Jj. Court et al., A NOVEL AND PRACTICAL METHOD FOR THE N-BROMOMETHYLATION OF IMIDES ANDISOTHIAZOLONE 1,1-DIOXIDES, Synlett, (5), 1995, pp. 423-424
BIOLOGICAL-ACTIVITY OF WIN-63759, AN ORALLY BIOAVAILABLE INHIBITOR OFHUMAN NEUTROPHIL ELASTASE
Authors: SILVER PJ GORDON RJ PAGANI ED JOHNSON JA MAYCOCK AL DUNLAP RP FERGUSON EW FRANKE CA DROZD ML ROBINSON DT EICKHOFF WM BAIZMAN ER SUBRAMANYAM C DESAI RC HLASTA DJ NEWTON JF
Citation: Pj. Silver et al., BIOLOGICAL-ACTIVITY OF WIN-63759, AN ORALLY BIOAVAILABLE INHIBITOR OFHUMAN NEUTROPHIL ELASTASE, Drug development research, 34(3), 1995, pp. 306-316
AN EFFICIENT LARGE-SCALE SYNTHESIS OF 4-ISOPROPYL-6-METHOXYBENZISOTHIAZOLONES AND 4-ISOPROPYL-6-METHOXYBENZISOTHIAZOLONES (VOL 59, PG 7162,1994)
Authors: DESAI RC HLASTA DJ MONSOUR G SAINDANE M
Citation: Rc. Desai et al., AN EFFICIENT LARGE-SCALE SYNTHESIS OF 4-ISOPROPYL-6-METHOXYBENZISOTHIAZOLONES AND 4-ISOPROPYL-6-METHOXYBENZISOTHIAZOLONES (VOL 59, PG 7162,1994), Journal of organic chemistry, 60(13), 1995, pp. 4308-4308
PHOSPHONATES AND PHOSPHINATES - NOVEL LEAVING GROUPS FOR BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
Authors: DESAI RC COURT JC FERGUSON E GORDON RJ HLASTA DJ DUNLAP RP FRANKE CA
Citation: Rc. Desai et al., PHOSPHONATES AND PHOSPHINATES - NOVEL LEAVING GROUPS FOR BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, Journal of medicinal chemistry, 38(9), 1995, pp. 1571-1574
ORALLY BIOAVAILABLE BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
Authors: HLASTA DJ SUBRAMANYAM C BELL MR CARABATEAS PM COURT JJ DESAI RC DROZD ML EICKHOFF WM FERGUSON EW GORDON RJ JOHNSON JA KUMAR V MAYCOCK AL MUELLER KR PAGANI ED ROBINSON DT SAINDANE MT SILVER PJ SUBRAMANIAN S DUNLAP RP FRANKE CA MURA AJ ROWLANDS AG
Citation: Dj. Hlasta et al., ORALLY BIOAVAILABLE BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, Journal of medicinal chemistry, 38(5), 1995, pp. 739-744
A NOVEL CLASS OF CYCLIC BETA-DICARBONYL LEAVING GROUPS AND THEIR USE IN THE DESIGN OF BENZISOTHIAZOLONE HUMAN-LEUKOCYTE ELASTASE INHIBITORS
Authors: HLASTA DJ ACKERMAN JH COURT JJ FARRELL RP JOHNSON JA KOFRON JL ROBINSON DT TALOMIE TG DUNLAP RP FRANKE CA
Citation: Dj. Hlasta et al., A NOVEL CLASS OF CYCLIC BETA-DICARBONYL LEAVING GROUPS AND THEIR USE IN THE DESIGN OF BENZISOTHIAZOLONE HUMAN-LEUKOCYTE ELASTASE INHIBITORS, Journal of medicinal chemistry, 38(23), 1995, pp. 4687-4692
2,6-DISUBSTITUTED ARYL CARBOXYLIC-ACIDS, LEAVING GROUPS PAR EXCELLENCE FOR BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE (VOL 37, PG 2625, 1994)
Authors: SUBRAMANYAM C BELL MR CARABATEAS P COURT JJ DORITY JA FERGUSON E GORDON R HLASTA DJ KUMAR V SAINDANE M DUNLAP RP FRANKE CA MURA AJ
Citation: C. Subramanyam et al., 2,6-DISUBSTITUTED ARYL CARBOXYLIC-ACIDS, LEAVING GROUPS PAR EXCELLENCE FOR BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE (VOL 37, PG 2625, 1994), Journal of medicinal chemistry, 38(16), 1995, pp. 3188-3188
A BENZISOTHIAZOLONE CLASS OF POTENT, SELECTIVE MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
Authors: HLASTA DJ BELL MR BOAZ NW COURT JJ DESAI RC FRANKE CA MURA AJ SUBRAMANYAM C DUNLAP RP
Citation: Dj. Hlasta et al., A BENZISOTHIAZOLONE CLASS OF POTENT, SELECTIVE MECHANISM-BASED INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, Bioorganic & medicinal chemistry letters, 4(15), 1994, pp. 1801-1806
A CONVIENT ONE-POT PROCEDURE FOR N-BROMOMETHYLATION OF IMIDE AND IMIDE-LIKE COMPOUNDS
Authors: DESAI RC FARRELL RP KUO GH HLASTA DJ
Citation: Rc. Desai et al., A CONVIENT ONE-POT PROCEDURE FOR N-BROMOMETHYLATION OF IMIDE AND IMIDE-LIKE COMPOUNDS, Synlett, (11), 1994, pp. 933-934
AN EFFICIENT LARGE-SCALE SYNTHESIS OF 4-ISOPROPYL-6-METHOXYBENZISOAZOLONE 4-ISOPROPYL-6-METHOXYBENZISOTHIAZOLONE
Authors: DESAI RC HLASTA DJ MONSOUR G SAINDANE MT
Citation: Rc. Desai et al., AN EFFICIENT LARGE-SCALE SYNTHESIS OF 4-ISOPROPYL-6-METHOXYBENZISOAZOLONE 4-ISOPROPYL-6-METHOXYBENZISOTHIAZOLONE, Journal of organic chemistry, 59(23), 1994, pp. 7161-7163
STERIC EFFECTS ON THE REGIOSELECTIVITY OF AN AZIDE-ALKYNE DIPOLAR CYCLOADDITION REACTION - THE SYNTHESIS OF HUMAN-LEUKOCYTE ELASTASE INHIBITORS
Authors: HLASTA DJ ACKERMAN JH
Citation: Dj. Hlasta et Jh. Ackerman, STERIC EFFECTS ON THE REGIOSELECTIVITY OF AN AZIDE-ALKYNE DIPOLAR CYCLOADDITION REACTION - THE SYNTHESIS OF HUMAN-LEUKOCYTE ELASTASE INHIBITORS, Journal of organic chemistry, 59(21), 1994, pp. 6184-6189
2,6-DISUBSTITUTED ARYL CARBOXYLIC-ACIDS, LEAVING GROUPS PAR EXCELLENCE FOR BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE
Authors: SUBRAMANYAM C BELL MR CARABATEAS P COURT JJ DORITY JA FERGUSON E GORDON R HLASTA DJ KUMAR V SAINDANE M DUNLAP RP FRANKE CA MURA AJ
Citation: C. Subramanyam et al., 2,6-DISUBSTITUTED ARYL CARBOXYLIC-ACIDS, LEAVING GROUPS PAR EXCELLENCE FOR BENZISOTHIAZOLONE INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE, Journal of medicinal chemistry, 37(17), 1994, pp. 2623-2626
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