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Results: 1-24 |
Results: 24
THE ECVAM INTERNATIONAL VALIDATION-STUDY ON IN-VITRO TESTS FOR SKIN CORROSIVITY - 2 - RESULTS AND EVALUATION BY THE MANAGEMENT TEAM
Authors: FENTEM JH ARCHER GEB BALLS M BOTHAM PA CURREN RD EARL LK ESDAILE DJ HOLZHUTTER HG LIEBSCH M
Citation: Jh. Fentem et al., THE ECVAM INTERNATIONAL VALIDATION-STUDY ON IN-VITRO TESTS FOR SKIN CORROSIVITY - 2 - RESULTS AND EVALUATION BY THE MANAGEMENT TEAM, Toxicology in vitro, 12(4), 1998, pp. 483-524
THE INTERNATIONAL EU COLIPA IN-VITRO PHOTOTOXICITY VALIDATION-STUDY -RESULTS OF PHASE-II (BLIND TRIAL) - PART 1 - THE 3T3 NRU PHOTOTOXICITY TEST/
Authors: SPIELMANN H BALLS M DUPUIS J PAPE WJ PECHOVITCH G DESILVA O HOLZHUTTER HG CLOTHIER R DESOLLE P GERBERICK F LIEBSCH M LOVELL WW MAURER T PFANNENBECKER U POTTHAST JM CSATO M SLADOWSKI D STEILING W BRANTOM P
Citation: H. Spielmann et al., THE INTERNATIONAL EU COLIPA IN-VITRO PHOTOTOXICITY VALIDATION-STUDY -RESULTS OF PHASE-II (BLIND TRIAL) - PART 1 - THE 3T3 NRU PHOTOTOXICITY TEST/, Toxicology in vitro, 12(3), 1998, pp. 305-327
A STUDY ON UV FILTER CHEMICALS FROM ANNEX-VII OF EUROPEAN-UNION DIRECTIVE 76 768/EEC, IN THE IN-VITRO 3T3 NRU PHOTOTOXICITY TEST/
Authors: SPIELMANN H BALLS M DUPUIS J PAPE WJW DESILVA O HOLZHUTTER HG GERBERICK F LIEBSCH M LOVELL WW PFANNENBECKER U
Citation: H. Spielmann et al., A STUDY ON UV FILTER CHEMICALS FROM ANNEX-VII OF EUROPEAN-UNION DIRECTIVE 76 768/EEC, IN THE IN-VITRO 3T3 NRU PHOTOTOXICITY TEST/, ATLA. Alternatives to laboratory animals, 26(5), 1998, pp. 679-708
IN-VITRO TESTING OF EMBRYOTOXICITY USING THE EMBRYONIC STEM-CELL TEST- AN INTER-LABORATORY COMPARISON
Authors: SCHOLZ G POHL I SEILER A BREMER S MOLDENHAUER F HOLZHUTTER HG SPIELMANN H
Citation: G. Scholz et al., IN-VITRO TESTING OF EMBRYOTOXICITY USING THE EMBRYONIC STEM-CELL TEST- AN INTER-LABORATORY COMPARISON, Naunyn-Schmiedeberg's archives of pharmacology, 357(4), 1998, pp. 606-606
IRAG WORKING GROUP 2 - CAM-BASED ASSAYS
Authors: SPIELMANN H LIEBSCH M MOLDENHAUER F HOLZHUTTER HG BAGLEY DM LIPMAN JM PAPE WJW MILTENBURGER H DESILVA O HOFER H STEILING W
Citation: H. Spielmann et al., IRAG WORKING GROUP 2 - CAM-BASED ASSAYS, Food and chemical toxicology, 35(1), 1997, pp. 39-66
APPENDIX I - STATISTICAL PLANNING AND ANALYSIS CONSIDERATIONS IN THE EVALUATION OF IN-VITRO ALTERNATIVES TO WHOLE ANIMAL USE FOR EYE IRRITATION TESTING
Authors: FEDER P CARR G HOLZHUTTER HG LOVELL D SPRINGER J
Citation: P. Feder et al., APPENDIX I - STATISTICAL PLANNING AND ANALYSIS CONSIDERATIONS IN THE EVALUATION OF IN-VITRO ALTERNATIVES TO WHOLE ANIMAL USE FOR EYE IRRITATION TESTING, Food and chemical toxicology, 35(1), 1997, pp. 167-174
THE VALIDATION OF TOXICOLOGICAL PREDICTION MODELS
Authors: ARCHER G BALLS M BRUNER LH CURREN RD FENTEM JH HOLZHUTTER HG LIEBSCH M LOVELL DP SOUTHEE JA
Citation: G. Archer et al., THE VALIDATION OF TOXICOLOGICAL PREDICTION MODELS, ATLA. Alternatives to laboratory animals, 25(5), 1997, pp. 505-516
A GENERAL MEASURE OF IN-VITRO PHOTOTOXICITY DERIVED FROM PAIRS OF DOSE-RESPONSE CURVES AND ITS USE FOR PREDICTING THE IN-VIVO PHOTOTOXICITYOF CHEMICALS
Authors: HOLZHUTTER HG
Citation: Hg. Holzhutter, A GENERAL MEASURE OF IN-VITRO PHOTOTOXICITY DERIVED FROM PAIRS OF DOSE-RESPONSE CURVES AND ITS USE FOR PREDICTING THE IN-VIVO PHOTOTOXICITYOF CHEMICALS, ATLA. Alternatives to laboratory animals, 25(4), 1997, pp. 445-462
MODELS FOR THE REGULATION OF PURINE METABOLISM IN RAT HEPATOCYTES - EVALUATION OF TRACER KINETIC-EXPERIMENTS
Authors: SCHWENDEL A GRUNE TG HOLZHUTTER HG SIEMS WG
Citation: A. Schwendel et al., MODELS FOR THE REGULATION OF PURINE METABOLISM IN RAT HEPATOCYTES - EVALUATION OF TRACER KINETIC-EXPERIMENTS, American journal of physiology: Gastrointestinal and liver physiology, 36(1), 1997, pp. 239-246
A KINETIC-MODEL FOR THE INTERACTION OF NITRIC-OXIDE WITH A MAMMALIAN LIPOXYGENASE
Authors: HOLZHUTTER HG WIESNER R RATHMANN J STOSSER R KUHN H
Citation: Hg. Holzhutter et al., A KINETIC-MODEL FOR THE INTERACTION OF NITRIC-OXIDE WITH A MAMMALIAN LIPOXYGENASE, European journal of biochemistry, 245(3), 1997, pp. 608-616
THE USE OF PREDICTION MODELS IN VALIDATION STUDIES - WHAT SHOULD THEYPREDICT
Authors: HOLZHUTTER HG SPIELMANN H
Citation: Hg. Holzhutter et H. Spielmann, THE USE OF PREDICTION MODELS IN VALIDATION STUDIES - WHAT SHOULD THEYPREDICT, ATLA. Alternatives to laboratory animals, 24(6), 1996, pp. 881-884
RESULTS OF A VALIDATION-STUDY IN GERMANY ON 2 IN-VITRO ALTERNATIVES TO THE DRAIZE EYE IRRITATION TEST, THE HET-CAM TEST AND THE 3T3 NRU CYTOTOXICITY TEST
Authors: SPIELMANN H LIEBSCH M KALWEIT S MOLDENHAUER F WIRNSBERGER T HOLZHUTTER HG SCHNEIDER B GLASER S GERNER I PAPE WJW KREILING R KRAUSER K MILTENBURGER HG STEILING W LUEPKE NP MULLER N KREUZER H MURMANN P SPENGLER J BERTRAMNEIS E SIEGEMUND B WIEBEL FJ
Citation: H. Spielmann et al., RESULTS OF A VALIDATION-STUDY IN GERMANY ON 2 IN-VITRO ALTERNATIVES TO THE DRAIZE EYE IRRITATION TEST, THE HET-CAM TEST AND THE 3T3 NRU CYTOTOXICITY TEST, ATLA. Alternatives to laboratory animals, 24(5), 1996, pp. 741-858
RECOMMENDATIONS FOR THE APPLICATION OF BIOSTATISTICAL METHODS DURING THE DEVELOPMENT AND VALIDATION OF ALTERNATIVE TOXICOLOGICAL METHODS - ECVAM BIOSTATISTICS TASK-FORCE REPORT 1
Authors: HOLZHUTTER HG ARCHER G DAMI N LOVELL DP SALTELLI A SJOSTROM M
Citation: Hg. Holzhutter et al., RECOMMENDATIONS FOR THE APPLICATION OF BIOSTATISTICAL METHODS DURING THE DEVELOPMENT AND VALIDATION OF ALTERNATIVE TOXICOLOGICAL METHODS - ECVAM BIOSTATISTICS TASK-FORCE REPORT 1, ATLA. Alternatives to laboratory animals, 24(4), 1996, pp. 511-530
NITRIC-OXIDE OXIDIZES A FERROUS MAMMALIAN LIPOXYGENASE TO A PRE-ACTIVATED FERRIC SPECIES
Authors: WIESNER R RATHMANN J HOLZHUTTER HG STOSSER R MADER K NOLTING H KUHN H
Citation: R. Wiesner et al., NITRIC-OXIDE OXIDIZES A FERROUS MAMMALIAN LIPOXYGENASE TO A PRE-ACTIVATED FERRIC SPECIES, FEBS letters, 389(3), 1996, pp. 229-232
MODERN BIOSTATISTICAL METHODS FOR ASSESSING IN-VITRO IN-VIVO CORRELATION OF SEVERELY EYE IRRITATING CHEMICALS IN A VALIDATION-STUDY OF IN-VITRO ALTERNATIVES TO THE DRAIZE EYE TEST
Authors: SPIELMANN H LIEBSCH M MOLDENHAUER F HOLZHUTTER HG DESILVA O
Citation: H. Spielmann et al., MODERN BIOSTATISTICAL METHODS FOR ASSESSING IN-VITRO IN-VIVO CORRELATION OF SEVERELY EYE IRRITATING CHEMICALS IN A VALIDATION-STUDY OF IN-VITRO ALTERNATIVES TO THE DRAIZE EYE TEST, Toxicology in vitro, 9(4), 1995, pp. 549-556
USE OF MATHEMATICAL-MODELS FOR PREDICTING THE METABOLIC EFFECT OF LARGE-SCALE ENZYME-ACTIVITY ALTERATIONS - APPLICATION TO ENZYME DEFICIENCIES OF RED-BLOOD-CELLS
Authors: SCHUSTER R HOLZHUTTER HG
Citation: R. Schuster et Hg. Holzhutter, USE OF MATHEMATICAL-MODELS FOR PREDICTING THE METABOLIC EFFECT OF LARGE-SCALE ENZYME-ACTIVITY ALTERATIONS - APPLICATION TO ENZYME DEFICIENCIES OF RED-BLOOD-CELLS, European journal of biochemistry, 229(2), 1995, pp. 403-418
TRANSITIONS OF HEPATIC PURINE METABOLISM OF EHRLICH ASCITES TUMOR-BEARING MICE IN DIFFERENT PHASES OF TUMOR-GROWTH
Authors: SCHWENDEL A SIEMS WG GRUNE T HOLZHUTTER HG
Citation: A. Schwendel et al., TRANSITIONS OF HEPATIC PURINE METABOLISM OF EHRLICH ASCITES TUMOR-BEARING MICE IN DIFFERENT PHASES OF TUMOR-GROWTH, Biochemistry and molecular biology international, 34(3), 1994, pp. 457-463
RAPID-EQUILIBRIUM APPROXIMATION APPLIED TO MATHEMATICAL-MODELS OF TRACER DYNAMICS IN BIOCHEMICAL REACTION SYSTEMS
Authors: SCHUSTER R HOLZHUTTER HG
Citation: R. Schuster et Hg. Holzhutter, RAPID-EQUILIBRIUM APPROXIMATION APPLIED TO MATHEMATICAL-MODELS OF TRACER DYNAMICS IN BIOCHEMICAL REACTION SYSTEMS, Mathematical and computer modelling, 19(6-8), 1994, pp. 241-253
MULTIPHASE SATURATION CURVES OF THE OXOGLUTARATE CARRIER - A MATHEMATICAL-MODEL
Authors: HOLZHUTTER HG SLUSEGOFFART CM SLUSE FE
Citation: Hg. Holzhutter et al., MULTIPHASE SATURATION CURVES OF THE OXOGLUTARATE CARRIER - A MATHEMATICAL-MODEL, Mathematical and computer modelling, 19(6-8), 1994, pp. 263-272
EEC COLIPA PROJECT ON IN-VITRO PHOTOTOXICITY TESTING - FIRST RESULTS OBTAINED WITH A BALB C 3T3 CELL PHOTOTOXICITY ASSAY/
Authors: SPIELMANN H BALLS M BRAND M DORING B HOLZHUTTER HG KALWEIT S KLECAK G EPLATTENIER HL LIEBSCH M LOVELL WW MAURER T MOLDENHAUER F MOORE L PAPE WJW PFANENBECKER U POTTHAST J DESILVA O STEILING W WILLSHAW A
Citation: H. Spielmann et al., EEC COLIPA PROJECT ON IN-VITRO PHOTOTOXICITY TESTING - FIRST RESULTS OBTAINED WITH A BALB C 3T3 CELL PHOTOTOXICITY ASSAY/, Toxicology in vitro, 8(4), 1994, pp. 793-796
ESTIMATION OF METABOLIC FLUX RATES IN LIVER PURINE CATABOLISM OF TUMOR-BEARING MICE BY COMPUTER-SIMULATION OF RADIOACTIVE-TRACER EXPERIMENTS
Authors: SIEMS WG SCHWENDEL A GRUNE T HOLZHUTTER HG UHLIG R
Citation: Wg. Siems et al., ESTIMATION OF METABOLIC FLUX RATES IN LIVER PURINE CATABOLISM OF TUMOR-BEARING MICE BY COMPUTER-SIMULATION OF RADIOACTIVE-TRACER EXPERIMENTS, Cell biochemistry and function, 12(1), 1994, pp. 1-9
INTERPRETATION OF THE INOTROPIC EFFECT OF 2,3-BUTANEDIONE MONOXIME ONTHE ISOMETRIC TWITCH OF GUINEA-PIG PAPILLARY-MUSCLE
Authors: LAMMERICH A HOLZHUTTER HG JANIAK R STORCH E GUNTHER J
Citation: A. Lammerich et al., INTERPRETATION OF THE INOTROPIC EFFECT OF 2,3-BUTANEDIONE MONOXIME ONTHE ISOMETRIC TWITCH OF GUINEA-PIG PAPILLARY-MUSCLE, General physiology and biophysics, 13(5), 1994, pp. 377-392
ESTIMATION OF STEADY-STATE FLUX RATES IN METABOLIC SYSTEMS BY COMPUTER-SIMULATIONS OF RADIOACTIVE-TRACER EXPERIMENTS
Authors: HOLZHUTTER HG SCHWENDEL A GRUNE T QUEDENAU J SIEMS W
Citation: Hg. Holzhutter et al., ESTIMATION OF STEADY-STATE FLUX RATES IN METABOLIC SYSTEMS BY COMPUTER-SIMULATIONS OF RADIOACTIVE-TRACER EXPERIMENTS, Computer applications in the biosciences, 9(5), 1993, pp. 573-580
INACTIVATION OF PROSTAGLANDIN-H SYNTHASE FROM SHEEP VESICULAR GLANDS BY ACETYLENIC FATTY-ACIDS
Authors: SCHEWE C BELOSLUDTSEV YY DEMIN PM HOLZHUTTER HG SCHEWE T MYAGKOVA GI EVSTIGNEEVA RP
Citation: C. Schewe et al., INACTIVATION OF PROSTAGLANDIN-H SYNTHASE FROM SHEEP VESICULAR GLANDS BY ACETYLENIC FATTY-ACIDS, Bioorganiceskaa himia, 19(5), 1993, pp. 548-554
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