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Results: 1-25 | 26-26
Results: 1-25/26
NOVEL ANTINEOPLASTIC AGENTS WITH EFFICACY AGAINST MULTIDRUG-RESISTANTTUMOR-CELLS
Authors: MEDINA JC SHAN B BECKMANN H FARRELL RP CLARK DL LEARNED RM ROCHE D LI A BAICHWAL V CASE C BAEUERLE PA ROSEN T JAEN JC
Citation: Jc. Medina et al., NOVEL ANTINEOPLASTIC AGENTS WITH EFFICACY AGAINST MULTIDRUG-RESISTANTTUMOR-CELLS, Bioorganic & medicinal chemistry letters, 8(19), 1998, pp. 2653-2656
IDENTIFICATION AND CHARACTERIZATION OF M4 SELECTIVE MUSCARINIC ANTAGONISTS
Authors: AUGELLISZAFRAN CE JAEN JC MORELAND DW NELSON CB PENVOSEYI JR SCHWARZ RD
Citation: Ce. Augelliszafran et al., IDENTIFICATION AND CHARACTERIZATION OF M4 SELECTIVE MUSCARINIC ANTAGONISTS, Bioorganic & medicinal chemistry letters, 8(15), 1998, pp. 1991-1996
2-AMINO-4H-3,1-BENZOXAZIN-4-ONES AS INHIBITORS OF C1R SERINE-PROTEASE
Authors: HAYS SJ CAPRATHE BW GILMORE JL AMIN N EMMERLING MR MICHAEL W NADIMPALLI R NATH R RASER KJ STAFFORD D WATSON D WANG K JAEN JC
Citation: Sj. Hays et al., 2-AMINO-4H-3,1-BENZOXAZIN-4-ONES AS INHIBITORS OF C1R SERINE-PROTEASE, Journal of medicinal chemistry, 41(7), 1998, pp. 1060-1067
DESIGN AND SYNTHESIS OF M1-SELECTIVE MUSCARINIC AGONISTS - (R)-(-)-(Z)-1-AZABICYCLO[2.2.1]HEPTAN-3-ONE, O-(3-(3'-METHOXYPHENYL)-2-PROPYNYL)OXIME MALEATE (CI-1017), A FUNCTIONALLY M1-SELECTIVE MUSCARINIC AGONIST
Authors: TECLE H BARRETT SD LAUFFER DJ AUGELLISZAFRAN C BRANN MR CALLAHAN MJ CAPRATHE BW DAVIS RE DOYLE PD EUBANKS D LIPINISKI W MIRZADEGAN T MOOS WH MORELAND DW NELSON CB PAVIA MR RABY C SCHWARZ RD SPENCER CJ THOMAS AJ JAEN JC
Citation: H. Tecle et al., DESIGN AND SYNTHESIS OF M1-SELECTIVE MUSCARINIC AGONISTS - (R)-(-)-(Z)-1-AZABICYCLO[2.2.1]HEPTAN-3-ONE, O-(3-(3'-METHOXYPHENYL)-2-PROPYNYL)OXIME MALEATE (CI-1017), A FUNCTIONALLY M1-SELECTIVE MUSCARINIC AGONIST, Journal of medicinal chemistry, 41(14), 1998, pp. 2524-2536
DEVELOPMENT OF M-1 SUBTYPE-SELECTIVE MUSCARINIC AGONISTS FOR ALZHEIMERS-DISEASE - TRANSLATION OF IN-VITRO SELECTIVITY INTO IN-VIVO EFFICACY
Authors: SCHWARZ RD CALLAHAN MJ DAVIS RE JAEN JC TECLE H
Citation: Rd. Schwarz et al., DEVELOPMENT OF M-1 SUBTYPE-SELECTIVE MUSCARINIC AGONISTS FOR ALZHEIMERS-DISEASE - TRANSLATION OF IN-VITRO SELECTIVITY INTO IN-VIVO EFFICACY, Drug development research, 40(2), 1997, pp. 133-143
EFFICIENT SYNTHESIS OF EXO-1-AZABICYCLO[2.2.1]HEPTAN-3-OL
Authors: BARRETT SD JAEN JC CAPRATHE BW THOMAS AJ TECLE H
Citation: Sd. Barrett et al., EFFICIENT SYNTHESIS OF EXO-1-AZABICYCLO[2.2.1]HEPTAN-3-OL, Organic preparations and procedures international, 29(3), 1997, pp. 330-335
PD102807 - A NOVEL M-4-SELECTIVE MUSCARINIC ANTAGONIST
Authors: GROSS J AUGELLISZAFRAN CE CZECHE S FRIEBE T JAEN JC PENVOSEYI JR SCHWARZ RD MUTSCHLER E LAMBRECHT G
Citation: J. Gross et al., PD102807 - A NOVEL M-4-SELECTIVE MUSCARINIC ANTAGONIST, Naunyn-Schmiedeberg's archives of pharmacology, 355(4), 1997, pp. 62-62
PHARMACOLOGICAL CHARACTERIZATION OF PD182807 - AN M4 SUBTYPE-SELECTIVE MUSCARINIC ANTAGONIST
Authors: SCHWARZ RD NELSON CB AUGELLISZAFRAN CE PENVOSE JR JAEN JC WILEY J FREY KA
Citation: Rd. Schwarz et al., PHARMACOLOGICAL CHARACTERIZATION OF PD182807 - AN M4 SUBTYPE-SELECTIVE MUSCARINIC ANTAGONIST, Life sciences, 60(13-14), 1997, pp. 10-10
FUNCTIONAL-CHARACTERIZATION OF PD102807 - A NOVEL M(4)-SELECTIVE MUSCARINIC ANTAGONIST
Authors: GROSS J AUGELLISZAFRAN CE CZECHE S FRIEBE T JAEN JC PENVOSEYI JR SCHWARZ RD MUTSCHLER E LAMBRECHT G
Citation: J. Gross et al., FUNCTIONAL-CHARACTERIZATION OF PD102807 - A NOVEL M(4)-SELECTIVE MUSCARINIC ANTAGONIST, Life sciences, 60(13-14), 1997, pp. 12-12
SYNTHESIS AND EVALUATION OF 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES AS C1R SERINE-PROTEASE INHIBITORS
Authors: GILMORE JL HAYS SJ CAPRATHE BW LEE C EMMERLING MR MICHAEL W JAEN JC
Citation: Jl. Gilmore et al., SYNTHESIS AND EVALUATION OF 2-ARYL-4H-3,1-BENZOXAZIN-4-ONES AS C1R SERINE-PROTEASE INHIBITORS, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 679-682
ACETYLCHOLINESTERASE INHIBITION BY FUSED DIHYDROQUINAZOLINE COMPOUNDS
Authors: JAEN JC GREGOR VE LEE C DAVIS R EMMERLING M
Citation: Jc. Jaen et al., ACETYLCHOLINESTERASE INHIBITION BY FUSED DIHYDROQUINAZOLINE COMPOUNDS, Bioorganic & medicinal chemistry letters, 6(6), 1996, pp. 737-742
ARYL 1-BUT-3-YNYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINES AS POTENTIAL ANTIPSYCHOTIC AGENTS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS
Authors: GLASE SA AKUNNE HC HEFFNER TG JAEN JC MACKENZIE RG MELTZER LT PUGSLEY TA SMITH SJ WISE LD
Citation: Sa. Glase et al., ARYL 1-BUT-3-YNYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINES AS POTENTIAL ANTIPSYCHOTIC AGENTS - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS, Journal of medicinal chemistry, 39(16), 1996, pp. 3179-3187
IDENTIFICATION OF A 3-HYDROXYLATED TACRINE METABOLITE IN RAT AND MAN - METABOLIC PROFILING IMPLICATIONS AND PHARMACOLOGY
Authors: POOL WF WOOLF TF REILY MD CAPRATHE BW EMMERLING MR JAEN JC
Citation: Wf. Pool et al., IDENTIFICATION OF A 3-HYDROXYLATED TACRINE METABOLITE IN RAT AND MAN - METABOLIC PROFILING IMPLICATIONS AND PHARMACOLOGY, Journal of medicinal chemistry, 39(15), 1996, pp. 3014-3018
Z-(+ -)-1-AZABICYCLO [2.2.1]HEPTAN-3-ONE, O-(3-ARYL-2-PROPYNYL) OXIMES AS POTENTIAL M1-SUBTYPE SELECTIVE MUSCARINIC AGONISTS/
Authors: TECLE H JAEN JC AUGELLISZAFRAN C BARRETT SD CAPRATHE BW LAUFFER DJ MIRZADEGAN T MOOS WH MORELAND DW PAVIA MR SCHWARZ RD THOMAS AJ DAVIS RE
Citation: H. Tecle et al., Z-(+ -)-1-AZABICYCLO [2.2.1]HEPTAN-3-ONE, O-(3-ARYL-2-PROPYNYL) OXIMES AS POTENTIAL M1-SUBTYPE SELECTIVE MUSCARINIC AGONISTS/, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 631-636
(+ -)-1-AZABICYCLO[2.2.1]HEPTAN-3-ONE, O-(3-METHYL-5-ARYL-2-PENTEN-4-YNYL) OXIMES - POTENT MUSCARINIC AGONISTS/
Authors: TECLE H LAUFFER DJ DAVIS RE MIRZADEGAN T MORELAND DW SCHWARZ RD THOMAS AJ RABY C EUBANKS D BRANN MR JAEN JC
Citation: H. Tecle et al., (+ -)-1-AZABICYCLO[2.2.1]HEPTAN-3-ONE, O-(3-METHYL-5-ARYL-2-PENTEN-4-YNYL) OXIMES - POTENT MUSCARINIC AGONISTS/, Bioorganic & medicinal chemistry letters, 5(6), 1995, pp. 637-642
MUTATIONS OF ASPARTATE-103 IN THE HM2 RECEPTOR AND ALTERATIONS IN RECEPTOR-BINDING PROPERTIES OF MUSCARINIC AGONISTS
Authors: SCHWARZ RD SPENCER CJ JAEN JC MIRZADEGAN T MORELAND D TECLE H THOMAS AJ
Citation: Rd. Schwarz et al., MUTATIONS OF ASPARTATE-103 IN THE HM2 RECEPTOR AND ALTERATIONS IN RECEPTOR-BINDING PROPERTIES OF MUSCARINIC AGONISTS, Life sciences, 56(11-12), 1995, pp. 923-929
ARYLENEYNE 1-AZABICYCLO[2.2.1]HEPTAN-3-ONE OXIMES - POTENT MUSCARINICAGONISTS
Authors: TECLE H LAUFFER DJ DAVIS RE MIRZADEGAN T MORELAND DW SCHWARZ RD THOMAS AJ RABY C JAEN JC
Citation: H. Tecle et al., ARYLENEYNE 1-AZABICYCLO[2.2.1]HEPTAN-3-ONE OXIMES - POTENT MUSCARINICAGONISTS, Life sciences, 56(11-12), 1995, pp. 1003-1003
IDENTIFICATION AND CHARACTERIZATION OF M1 SELECTIVE MUSCARINIC ANTAGONISTS
Authors: AUGELLISZAFRAN CE BLANKLEY CJ JAEN JC MORELAND DW NELSON CB PENVOSE JR SCHWARZ RD THOMAS AJ
Citation: Ce. Augelliszafran et al., IDENTIFICATION AND CHARACTERIZATION OF M1 SELECTIVE MUSCARINIC ANTAGONISTS, Life sciences, 56(11-12), 1995, pp. 1017-1017
PHARMACOLOGICAL CHARACTERIZATION OF PD150714 - AN M1 SELECTIVE MUSCARINIC ANTAGONIST
Authors: NELSON CB AUGELLISZAFRAN CE CALLAHAN MJ CHRISTOFFERSEN C JAEN JC MELTZER LT PENVOSE JR SCHWARZ RD THOMAS AJ WILEY J
Citation: Cb. Nelson et al., PHARMACOLOGICAL CHARACTERIZATION OF PD150714 - AN M1 SELECTIVE MUSCARINIC ANTAGONIST, Life sciences, 56(11-12), 1995, pp. 1017-1017
CI-1007, A DOPAMINE PARTIAL AGONIST AND POTENTIAL ANTIPSYCHOTIC AGENT.1. NEUROCHEMICAL EFFECTS
Authors: PUGSLEY TA DAVIS MD AKUNNE HC COOKE LW WHETZEL SZ MACKENZIE RG SHIH YH VANLEEUWEN DH DEMATTOS SB GEORGIC LM CAPRATHE BW WRIGHT JC JAEN JC WISE LD HEFFNER TG
Citation: Ta. Pugsley et al., CI-1007, A DOPAMINE PARTIAL AGONIST AND POTENTIAL ANTIPSYCHOTIC AGENT.1. NEUROCHEMICAL EFFECTS, The Journal of pharmacology and experimental therapeutics, 274(2), 1995, pp. 898-911
KYNURENIC ACID-DERIVATIVES INHIBIT THE BINDING OF NERVE GROWTH-FACTOR(NGF) TO THE LOW-AFFINITY P75 NGF RECEPTOR
Authors: JAEN JC LABORDE E BUCSH RA CAPRATHE BW SORENSON RJ FERGUS J SPIEGEL K MARKS J DICKERSON MR DAVIS RE
Citation: Jc. Jaen et al., KYNURENIC ACID-DERIVATIVES INHIBIT THE BINDING OF NERVE GROWTH-FACTOR(NGF) TO THE LOW-AFFINITY P75 NGF RECEPTOR, Journal of medicinal chemistry, 38(22), 1995, pp. 4439-4445
PD-90780, A NONPEPTIDE INHIBITOR OF NERVE GROWTH-FACTORS BINDING TO THE P75 NGF RECEPTOR
Authors: SPIEGEL K AGRAFIOTIS D CAPRATHE B DAVIS RE DICKERSON MR FERGUS JH HEPBURN TW MARKS JS VANDORF M WIELAND DM JAEN JC
Citation: K. Spiegel et al., PD-90780, A NONPEPTIDE INHIBITOR OF NERVE GROWTH-FACTORS BINDING TO THE P75 NGF RECEPTOR, Biochemical and biophysical research communications, 217(2), 1995, pp. 488-494
THE DISCOVERY AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF YDRO-4-PHENYL-1-[(ARYLCYCLOHEXENYL)ALKYL]PYRIDINES - DOPAMINE AUTORECEPTOR AGONISTS AND POTENTIAL ANTIPSYCHOTIC AGENTS
Authors: WRIGHT JL CAPRATHE BW DOWNING DM GLASE SA HEFFNER TG JAEN JC JOHNSON SJ KESTEN SR MACKENZIE RG MELTZER LT PUGSLEY TA SMITH SJ WISE LD WUSTROW DJ
Citation: Jl. Wright et al., THE DISCOVERY AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF YDRO-4-PHENYL-1-[(ARYLCYCLOHEXENYL)ALKYL]PYRIDINES - DOPAMINE AUTORECEPTOR AGONISTS AND POTENTIAL ANTIPSYCHOTIC AGENTS, Journal of medicinal chemistry, 37(21), 1994, pp. 3523-3533
ASSESSMENT OF MUTAGENIC POTENTIAL IN A SERIES OF COMPOUNDS STRUCTURALLY RELATED TO 2-AMINO-3-METHYLIMIDAZO [4,5-F]QUINOLINE (IQ)
Authors: JAEN JC KROPKO ML THEISS JC WOLD S CAPRATHE BW WISE LD
Citation: Jc. Jaen et al., ASSESSMENT OF MUTAGENIC POTENTIAL IN A SERIES OF COMPOUNDS STRUCTURALLY RELATED TO 2-AMINO-3-METHYLIMIDAZO [4,5-F]QUINOLINE (IQ), European journal of medicinal chemistry, 28(7-8), 1993, pp. 547-553
PHARMACOLOGICAL PROFILE OF THE DOPAMINE PARTIAL AGONIST, (+ --PD-128483 AND ITS ENANTIOMERS/
Authors: MELTZER LT CAPRATHE BW CHRISTOFFERSEN CL CORBIN AE JAEN JC NINTEMAN FW PUGSLEY TA SERPA KA SHIH YH WHETZEL SZ WILEY JN WISE LD HEFFNER TG
Citation: Lt. Meltzer et al., PHARMACOLOGICAL PROFILE OF THE DOPAMINE PARTIAL AGONIST, (+ --PD-128483 AND ITS ENANTIOMERS/, The Journal of pharmacology and experimental therapeutics, 266(3), 1993, pp. 1177-1189
Risultati: 1-25 | 26-26