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Results: 1-20 |
Results: 20
Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase
Authors: Masson, P Xie, WH Froment, MT Lockridge, O
Citation: P. Masson et al., Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase, BBA-PROT ST, 1544(1-2), 2001, pp. 166-176
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: Supersensitivity of acetylcholinesterase knockout mouse to VX lethality
Authors: Duysen, EG Li, B Xie, WH Schopfer, LM Anderson, RS Broomfield, CA Lockridge, O
Citation: Eg. Duysen et al., Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: Supersensitivity of acetylcholinesterase knockout mouse to VX lethality, J PHARM EXP, 299(2), 2001, pp. 528-535
Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase - Engineering effective butyrylcholinesterase mutants for cocaine detoxication
Authors: Sun, H El Yazal, J Lockridge, O Schopfer, LM Brimijoin, S Pang, YP
Citation: H. Sun et al., Predicted Michaelis-Menten complexes of cocaine-butyrylcholinesterase - Engineering effective butyrylcholinesterase mutants for cocaine detoxication, J BIOL CHEM, 276(12), 2001, pp. 9330-9336
Pesticides and susceptible populations: People with butyrylcholinesterase genetic variants may be at risk
Authors: Lockridge, O Masson, P
Citation: O. Lockridge et P. Masson, Pesticides and susceptible populations: People with butyrylcholinesterase genetic variants may be at risk, NEUROTOXICO, 21(1-2), 2000, pp. 113-126
Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
Authors: Xie, WH Stribley, JA Chatonnet, A Wilder, PJ Rizzino, A McComb, RD Taylor, P Hinrichs, SH Lockridge, O
Citation: Wh. Xie et al., Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase, J PHARM EXP, 293(3), 2000, pp. 896-902
Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
Authors: Li, B Stribley, JA Ticu, A Xie, WH Schopfer, LM Hammond, P Brimijoin, S Hinrichs, SH Lockridge, O
Citation: B. Li et al., Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse, J NEUROCHEM, 75(3), 2000, pp. 1320-1331
The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme
Authors: Altamirano, CV Bartels, CF Lockridge, O
Citation: Cv. Altamirano et al., The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme, J NEUROCHEM, 74(2), 2000, pp. 869-877
Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma
Authors: Bartels, CF Xie, WH Miller-Lindholm, AK Schopfer, LM Lockridge, O
Citation: Cf. Bartels et al., Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma, BIOCH PHARM, 60(4), 2000, pp. 479-487
Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates
Authors: Masson, P Xie, WH Froment, MT Levitsky, V Fortier, PL Albaret, C Lockridge, O
Citation: P. Masson et al., Interaction between the peripheral site residues of human butyrylcholinesterase, D70 and Y332, in binding and hydrolysis of substrates, BBA-PROT ST, 1433(1-2), 1999, pp. 281-293
Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant
Authors: Levitsky, V Xie, WH Froment, MT Lockridge, O Masson, P
Citation: V. Levitsky et al., Polyol-induced activation by excess substrate of the D70G butyrylcholinesterase mutant, BBA-PROT ST, 1429(2), 1999, pp. 422-430
An improved cocaine hydrolase: The A328Y mutant of human butyrylcholinesterase is 4-fold more efficient
Authors: Xie, WH Altamirano, CV Bartels, CF Speirs, RJ Cashman, JR Lockridge, O
Citation: Wh. Xie et al., An improved cocaine hydrolase: The A328Y mutant of human butyrylcholinesterase is 4-fold more efficient, MOLEC PHARM, 55(1), 1999, pp. 83-91
Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process
Authors: Masson, P Fortier, PL Albaret, C Clery, C Guerra, P Lockridge, O
Citation: P. Masson et al., Structural and hydration changes in the active site gorge of phosporhylated butyrylcholinesterase accompanying the aging process, CHEM-BIO IN, 120, 1999, pp. 17-27
Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus
Authors: Altamirano, CV Lockridge, O
Citation: Cv. Altamirano et O. Lockridge, Association of tetramers of human butyrylcholinesterase is mediated by conserved aromatic residues of the carboxy terminus, CHEM-BIO IN, 120, 1999, pp. 53-60
Differences in active-site gorge dimensions of cholinesterases revealed bybinding of inhibitors to human butyrylcholinesterase
Authors: Saxena, A Redman, AMG Jiang, XL Lockridge, O Doctor, BP
Citation: A. Saxena et al., Differences in active-site gorge dimensions of cholinesterases revealed bybinding of inhibitors to human butyrylcholinesterase, CHEM-BIO IN, 120, 1999, pp. 61-69
Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis
Authors: Josse, D Xie, WH Masson, P Lockridge, O
Citation: D. Josse et al., Human serum paraoxonase (PON1): identification of essential amino acid residues by group-selective labelling and site-directed mutagenesis, CHEM-BIO IN, 120, 1999, pp. 71-78
Tryptophan residue(s) as major components of the human serum paraoxonase active site
Authors: Josse, D Xie, WH Masson, P Schopfer, LM Lockridge, O
Citation: D. Josse et al., Tryptophan residue(s) as major components of the human serum paraoxonase active site, CHEM-BIO IN, 120, 1999, pp. 79-84
Knockout of one acetylcholinesterase allele in the mouse
Authors: Xie, WH Wilder, PJ Stribley, J Chatonnet, A Rizzino, A Taylor, P Hinrichs, SH Lockridge, O
Citation: Wh. Xie et al., Knockout of one acetylcholinesterase allele in the mouse, CHEM-BIO IN, 120, 1999, pp. 289-299
Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization
Authors: Broomfield, CA Lockridge, O Millard, CB
Citation: Ca. Broomfield et al., Protein engineering of a human enzyme that hydrolyzes V and G nerve agents: design, construction and characterization, CHEM-BIO IN, 120, 1999, pp. 413-418
Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities
Authors: Josse, D Xie, WH Renault, F Rochu, D Schopfer, LM Masson, P Lockridge, O
Citation: D. Josse et al., Identification of residues essential for human paraoxonase (PON1) arylesterase/organophosphatase activities, BIOCHEM, 38(9), 1999, pp. 2816-2825
Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers
Authors: Altamirano, CV Lockridge, O
Citation: Cv. Altamirano et O. Lockridge, Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers, BIOCHEM, 38(40), 1999, pp. 13414-13422
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