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Results: 1-12 |
Results: 12
Computing in drug discovery: The design phase
Authors: Lunney, EA
Citation: Ea. Lunney, Computing in drug discovery: The design phase, COMPUT SC E, 3(5), 2001, pp. 105-108
Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide
Authors: Shahripour, AB Plummer, MS Lunney, EA Sawyer, TK Stankovic, CJ Connolly, MK Rubin, JR Walker, NPC Brady, KD Allen, HJ Talanian, RV Wong, WW Humblet, C
Citation: Ab. Shahripour et al., Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide, BIOORG MED, 11(20), 2001, pp. 2779-2782
4-hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: The effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters
Authors: Hagen, SE Domagala, J Gajda, C Lovdahl, M Tait, BD Wise, E Holler, T Hupe, D Nouhan, C Urumov, A Zeikus, G Zeikus, E Lunney, EA Pavlovsky, A Gracheck, SJ Saunders, J VanderRoest, S Brodfuehrer, J
Citation: Se. Hagen et al., 4-hydroxy-5,6-dihydropyrones as inhibitors of HIV protease: The effect of heterocyclic substituents at C-6 on antiviral potency and pharmacokinetic parameters, J MED CHEM, 44(14), 2001, pp. 2319-2332
Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors
Authors: Parker, MH Ortwine, DF O'Brien, PM Lunney, EA Banotai, CA Mueller, WT McConnell, P Brouillette, CG
Citation: Mh. Parker et al., Stereoselective binding of an enantiomeric pair of stromelysin-1 inhibitors caused by conformational entropy factors, BIOORG MED, 10(21), 2000, pp. 2427-2430
X-ray structures of five renin inhibitors bound to saccharopepsin: Exploration of active-site specificity
Authors: Cronin, NB Badasso, MO Tickle, IJ Dreyer, T Hoover, DJ Rosati, RL Humblet, CC Lunney, EA Cooper, JB
Citation: Nb. Cronin et al., X-ray structures of five renin inhibitors bound to saccharopepsin: Exploration of active-site specificity, J MOL BIOL, 303(5), 2000, pp. 745-760
5,6-dihydropyran-2-ones possessing various sulfonyl functionalities: Potent nonpeptidic inhibitors of HIV protease
Authors: Boyer, FE Prasad, JVNV Domagala, JM Ellsworth, EL Gajda, C Hagen, SE Markoski, LJ Tait, BD Lunney, EA Palovsky, A Ferguson, D Graham, N Holler, T Hupe, D Nouhan, C Tummino, PJ Urumov, A Zeikus, E Zeikus, G Gracheck, SJ Sanders, JM VanderRoest, S Brodfuehrer, J Iyer, K Sinz, M Gulnik, SV Erickson, JW
Citation: Fe. Boyer et al., 5,6-dihydropyran-2-ones possessing various sulfonyl functionalities: Potent nonpeptidic inhibitors of HIV protease, J MED CHEM, 43(5), 2000, pp. 843-858
Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: A lead HIV protease inhibitor
Authors: Prasad, JVNV Boyer, FE Domagala, JM Ellsworth, EL Gajda, C Hamilton, HW Hagen, SE Markoski, LJ Steinbaugh, BA Tait, BD Humblet, C Lunney, EA Pavlovsky, A Rubin, JR Ferguson, D Graham, N Holler, T Hupe, D Nouhan, C Tummino, PJ Urumov, A Zeikus, E Zeikus, G Gracheck, SJ Saunders, JM VanderRoest, S Brodfuehrer, J Iyer, K Sinz, M Gulnik, SV Erickson, JW
Citation: Jvnv. Prasad et al., Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: A lead HIV protease inhibitor, BIO MED CH, 7(12), 1999, pp. 2775-2800
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety.
Authors: Prasad, JVNV Markoski, LJ Boyer, FE Domagala, JM Ellsworth, EL Gajda, C Hagen, SE Tait, BD Lunney, EA Tummino, PJ Ferguson, D Holler, T Hupe, D Nouhan, C Gracheck, SJ VanderRoest, S Saunders, J Iyer, K Sinz, M
Citation: Jvnv. Prasad et al., Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety., BIOORG MED, 9(15), 1999, pp. 2217-2222
4-Hydroxy-5,6-dihydro-2H-pyran-2-ones. 3. Bicyclic and heteroaromatic ringsystems as 3-position scaffolds to bind to S-1 ' and S-2 ' of the HIV-1 protease enzyme.
Authors: Ellsworth, EL Domagala, J Prasad, JVNV Hagen, S Ferguson, D Holler, T Hupe, D Graham, N Nouhan, C Tummino, PJ Zeikus, G Lunney, EA
Citation: El. Ellsworth et al., 4-Hydroxy-5,6-dihydro-2H-pyran-2-ones. 3. Bicyclic and heteroaromatic ringsystems as 3-position scaffolds to bind to S-1 ' and S-2 ' of the HIV-1 protease enzyme., BIOORG MED, 9(14), 1999, pp. 2019-2024
Nonpeptidic HIV protease inhibitors: 6-alkyl-5, 6-dihydroyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl, 5-methylphenyl trio) moiety: Antiviral activities and pharmacokinetic properties
Authors: Prasad, JVNV Boyer, FE Domagala, JM Ellsworth, EL Gajda, C Hagen, SE Markoski, LJ Tait, BD Lunney, EA Tummino, PJ Ferguson, D Holler, T Hupe, D Nouhan, C Gracheck, SJ VanderRoest, S Saunders, J Iyer, K Sinz, M Brodfuehrer, J
Citation: Jvnv. Prasad et al., Nonpeptidic HIV protease inhibitors: 6-alkyl-5, 6-dihydroyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl, 5-methylphenyl trio) moiety: Antiviral activities and pharmacokinetic properties, BIOORG MED, 9(11), 1999, pp. 1481-1486
Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry
Authors: Parker, MH Lunney, EA Ortwine, DF Pavlovsky, AG Humblet, C Brouillette, CG
Citation: Mh. Parker et al., Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry, BIOCHEM, 38(41), 1999, pp. 13592-13601
Structure-based drug design begins a new era
Authors: Lunney, EA
Citation: Ea. Lunney, Structure-based drug design begins a new era, MED CHEM RE, 8(7-8), 1998, pp. 352-361
Risultati: 1-12 |