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Results: 1-25/28
Authors:
Jin, Y
Penning, TM
Citation: Y. Jin et Tm. Penning, Steroid 5 alpha-reductases and 3 alpha-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism, BEST PRAC R, 15(1), 2001, pp. 79-94
Authors:
Tsuruda, L
Hou, YT
Penning, TM
Citation: L. Tsuruda et al., Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death, CHEM RES T, 14(7), 2001, pp. 856-862
Authors:
Penning, TM
Burczynski, ME
Jez, JM
Lin, HK
Ma, HC
Moore, M
Ratnam, K
Palackal, N
Citation: Tm. Penning et al., Structure-function aspects and inhibitor design of type 5 17 beta-hydroxysteroid dehydrogenase (AKR1C3), MOL C ENDOC, 171(1-2), 2001, pp. 137-149
Authors:
Sridhar, GR
Murty, VS
Lee, SH
Blair, IA
Penning, TM
Citation: Gr. Sridhar et al., Amino acid adducts of PAH o-quinones: model studies with naphthalene-1,2-dione, TETRAHEDRON, 57(2), 2001, pp. 407-412
Authors:
Burczynski, ME
Sridhar, GR
Palackal, NT
Penning, TM
Citation: Me. Burczynski et al., The reactive oxygen species- and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroacy-2-nonenal to 1,4-dihydroxy-2-nonene, J BIOL CHEM, 276(4), 2001, pp. 2890-2897
Authors:
Jez, JM
Penning, TM
Citation: Jm. Jez et Tm. Penning, The aldo-keto reductase (AKR) superfamily: an update, CHEM-BIO IN, 130(1-3), 2001, pp. 499-525
Authors:
Penning, TM
Ma, HC
Jez, JM
Citation: Tm. Penning et al., Engineering steroid hormone specificity into aldo-keto reductases, CHEM-BIO IN, 130(1-3), 2001, pp. 659-671
Authors:
Palackal, NT
Burczynski, ME
Harvey, RG
Penning, TM
Citation: Nt. Palackal et al., Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiolsby ubiquitously expressed aldehyde reductase (AKR1A1), CHEM-BIO IN, 130(1-3), 2001, pp. 815-824
Authors:
Penning, TM
Jez, JM
Citation: Tm. Penning et Jm. Jez, Enzyme redesign, CHEM REV, 101(10), 2001, pp. 3027-3046
Authors:
Palackal, NT
Burczynski, ME
Harvey, RG
Penning, TM
Citation: Nt. Palackal et al., The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: Potential role in polycyclic aromatic hydrocarbon activation, BIOCHEM, 40(36), 2001, pp. 10901-10910
Authors:
Jin, Y
Stayrook, SE
Albert, RH
Palackal, NT
Penning, TM
Lewis, M
Citation: Y. Jin et al., Crystal structure of human type III 3 alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate, BIOCHEM, 40(34), 2001, pp. 10161-10168
Authors:
Bolton, JL
Trush, MA
Penning, TM
Dryhurst, G
Monks, TJ
Citation: Jl. Bolton et al., Role of quinones in toxicology, CHEM RES T, 13(3), 2000, pp. 135-160
Authors:
Penning, TM
Burczynski, ME
Jez, JM
Hung, CF
Lin, HK
Ma, HC
Moore, M
Palackal, N
Ratnam, K
Citation: Tm. Penning et al., Human 3 alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of thealdo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sexhormones, BIOCHEM J, 351, 2000, pp. 67-77
Authors:
Hardy, DO
Ge, RS
Catterall, JF
Hou, YT
Penning, TM
Hardy, MP
Citation: Do. Hardy et al., Identification of the oxidative 3 alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase, ENDOCRINOL, 141(5), 2000, pp. 1608-1617
Authors:
Burczynski, ME
Penning, TM
Citation: Me. Burczynski et Tm. Penning, Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor, CANCER RES, 60(4), 2000, pp. 908-915
Authors:
Ma, HC
Ratnam, K
Penning, TM
Citation: Hc. Ma et al., Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding, BIOCHEM, 39(1), 2000, pp. 102-109
Authors:
Harvey, RG
Penning, TM
Jarabak, J
Zhang, FJ
Citation: Rg. Harvey et al., Role of quinone metabolites in PAH carcinogenesis, POLYCYCL AR, 16(1-4), 1999, pp. 13-20
Authors:
Burczynski, ME
Palackal, NT
Harvey, RG
Penning, TM
Citation: Me. Burczynski et al., Polycyclic aromatic hydrocarbon trans-dihydrodiol specificity of four recombinant human dihydrodiol dehydrogenase isoforms, POLYCYCL AR, 16(1-4), 1999, pp. 205-214
Authors:
Lin, HK
Hung, CF
Moore, M
Penning, TM
Citation: Hk. Lin et al., Genomic structure of rat 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase (3 alpha-HSD/DD, AKR1C9), J STEROID B, 71(1-2), 1999, pp. 29-39
Authors:
Penning, TM
Citation: Tm. Penning, Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3 alpha-hydroxysteroid dehydrogenase, J STEROID B, 69(1-6), 1999, pp. 211-225
Authors:
McCoull, KD
Rindgen, D
Blair, IA
Penning, TM
Citation: Kd. Mccoull et al., Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts, CHEM RES T, 12(3), 1999, pp. 237-246
Authors:
Penning, TM
Burczynski, ME
Hung, CF
McCoull, KD
Palackal, NT
Tsuruda, LS
Citation: Tm. Penning et al., Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation:Generation of reactive and redox active o-quinones, CHEM RES T, 12(1), 1999, pp. 1-18
Authors:
Hung, CF
Penning, TM
Citation: Cf. Hung et Tm. Penning, Members of the nuclear factor 1 transcription factor family regulate rat 3alpha-hydroxysteroid/dihydrodiol dihydrodiol dehydrogenase (3 alpha-HSD/DDAKR1C9) gene expression: A member of the aldo-keto reductase superfamily, MOL ENDOCR, 13(10), 1999, pp. 1704-1717
Authors:
Ma, HC
Penning, TM
Citation: Hc. Ma et Tm. Penning, Characterization of homogeneous recombinant rat ovarian 20 alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile, BIOCHEM J, 341, 1999, pp. 853-859
Authors:
Ma, HC
Penning, TM
Citation: Hc. Ma et Tm. Penning, Conversion of mammalian 3 alpha-hydroxysteroid dehydrogenase to 20 alpha-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins, P NAS US, 96(20), 1999, pp. 11161-11166