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Results: 1-12 |
Results: 12
Synthesis of rofecoxib, (MK 0966, Vioxx((R)) 4-(4 '-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2
Authors: Therien, M Gauthier, JY Leblanc, Y Leger, S Perrier, H Prasit, P Wang, ZI
Citation: M. Therien et al., Synthesis of rofecoxib, (MK 0966, Vioxx((R)) 4-(4 '-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone), a selective and orally active inhibitor of cyclooxygenase-2, SYNTHESIS-S, (12), 2001, pp. 1778-1779
Etoricoxib (MK-0663): Preclinical profile and comparison with other agentsthat selectively inhibit cyclooxygenase-2
Authors: Riendeau, D Percival, MD Brideau, C Charleson, S Dube, D Ethier, D Falgueyret, JP Friesen, RW Gordon, R Greig, G Guay, J Mancini, J Ouellet, M Wong, E Xu, L Boyce, S Visco, D Girard, Y Prasit, P Zamboni, R Rodger, IW Gresser, M Ford-Hutchinson, AW Young, RN Chan, CC
Citation: D. Riendeau et al., Etoricoxib (MK-0663): Preclinical profile and comparison with other agentsthat selectively inhibit cyclooxygenase-2, J PHARM EXP, 296(2), 2001, pp. 558-566
Novel, nonpeptidic cyanamides as potent and reversible inhibitors of humancathepsins K and L
Authors: Falgueyret, JP Oballa, RM Okamoto, O Wesolowski, G Aubin, Y Rydzewski, RM Prasit, P Riendeau, D Rodan, SB Percival, MD
Citation: Jp. Falgueyret et al., Novel, nonpeptidic cyanamides as potent and reversible inhibitors of humancathepsins K and L, J MED CHEM, 44(1), 2001, pp. 94-104
Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx (TM))
Authors: Nicoll-Griffith, DA Yergey, JA Trimble, LA Silva, JM Li, C Chauret, N Gauthier, JY Grimm, E Leger, S Roy, P Therien, M Wang, ZY Prasit, P Zamboni, R Young, RN Brideau, C Chan, CC Mancini, J Riendeau, D
Citation: Da. Nicoll-griffith et al., Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx (TM)), BIOORG MED, 10(23), 2000, pp. 2683-2686
A new structural variation on the methanesulfonylphenyl class of selectivecyclooxygenase-2 inhibitors
Authors: Li, CS Black, WC Brideau, C Chan, CC Charleson, S Cromlish, WA Claveau, D Gauthier, JY Gordon, R Greig, G Grimm, E Guay, J Lau, CK Riendeau, D Therien, M Visco, DM Wong, E Xu, LJ Prasit, P
Citation: Cs. Li et al., A new structural variation on the methanesulfonylphenyl class of selectivecyclooxygenase-2 inhibitors, BIOORG MED, 9(22), 1999, pp. 3181-3186
Synthesis and biological evaluation of 3-heteroarizoxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors
Authors: Lau, CK Brideau, C Chan, CC Charleson, S Cromlish, WA Ethier, D Gauthier, JY Gordon, R Guay, J Kargman, S Li, CS Prasit, P Riendeau, D Therien, M Visco, DM Xu, LJ
Citation: Ck. Lau et al., Synthesis and biological evaluation of 3-heteroarizoxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors, BIOORG MED, 9(22), 1999, pp. 3187-3192
Substituted heterocyclic analogs as selective COX-2 inhibitors in the Flosulide class
Authors: Ouimet, N Chan, CC Charleson, S Claveau, D Gordon, R Guay, D Li, CS Ouellet, M Percival, DM Riendeau, D Wong, E Zamboni, R Prasit, P
Citation: N. Ouimet et al., Substituted heterocyclic analogs as selective COX-2 inhibitors in the Flosulide class, BIOORG MED, 9(2), 1999, pp. 151-156
Sar in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor
Authors: Leblanc, Y Roy, P Boyce, S Brideau, C Chan, CC Charleson, S Gordon, R Grimm, E Guay, J Leger, S Li, CS Riendeau, D Visco, D Wang, Z Webb, J Xu, LJ Prasit, P
Citation: Y. Leblanc et al., Sar in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor, BIOORG MED, 9(15), 1999, pp. 2207-2212
The discovery of rofecoxib, [MK 966, Vioxx (R), 4-(4 '-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor
Authors: Prasit, P Wang, Z Brideau, C Chan, CC Charleson, S Cromlish, W Ethier, D Evans, JF Ford-Hutchinson, AW Gauthier, JY Gordon, R Guay, J Gresser, M Kargman, S Kennedy, B Leblanc, Y Leger, S Mancini, J O'Neill, GP Ouellet, M Percival, MD Perrier, H Riendeau, D Rodger, I Tagari, P Therien, M Vickers, P Wong, E Xu, LJ Young, RN Zamboni, R Boyce, S Rupniak, N Forrest, N Visco, D Patrick, D
Citation: P. Prasit et al., The discovery of rofecoxib, [MK 966, Vioxx (R), 4-(4 '-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2 inhibitor, BIOORG MED, 9(13), 1999, pp. 1773-1778
Efficient syntheses of 2-(3 ',5 '-difluorophenyl)-3-(4 '-methylsulfonylphenyl)-cyclopent-2-enone, a potent COX-2 inhibitor
Authors: Zhaol, DL Xu, F Chen, CY Tillyer, RD Grabowski, EJJ Reider, PJ Black, C Ouimet, N Prasit, P
Citation: Dl. Zhaol et al., Efficient syntheses of 2-(3 ',5 '-difluorophenyl)-3-(4 '-methylsulfonylphenyl)-cyclopent-2-enone, a potent COX-2 inhibitor, TETRAHEDRON, 55(19), 1999, pp. 6001-6018
Rofecoxib [Vioxx, MK-0966; 4-(4 '-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles
Authors: Chan, CC Boyce, S Brideau, C Charleson, S Cromlish, W Ethier, D Evans, J Ford-Hutchinson, AW Forrest, MJ Gauthier, JY Gordon, R Gresser, M Guay, J Kargman, S Kennedy, B Leblanc, Y Leger, S Mancini, J O'Neill, GP Ouellet, M Patrick, D Percival, MD Perrier, H Prasit, P Rodger, I Tagari, P Therien, M Vickers, P Visco, D Wang, Z Webb, J Wong, E Xu, LJ Young, RN Zamboni, R Riendeau, D
Citation: Cc. Chan et al., Rofecoxib [Vioxx, MK-0966; 4-(4 '-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: A potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles, J PHARM EXP, 290(2), 1999, pp. 551-560
2,3-diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors
Authors: Black, WC Brideau, C Chan, CC Charleson, S Chauret, N Claveau, D Ethier, D Gordon, R Greig, G Guay, J Hughes, G Jolicoeur, P Leblanc, Y Nicoll-Griffith, D Ouimet, N Riendeau, D Visco, D Wang, ZY Xu, L Prasit, P
Citation: Wc. Black et al., 2,3-diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors, J MED CHEM, 42(7), 1999, pp. 1274-1281
Risultati: 1-12 |