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Results: 1-25 | 26-50 | 51-53
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DETECTION OF A NEW SUBSTRATE-DERIVED RADICAL DURING INACTIVATION OF RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA-COLI BY GEMCITABINE 5'-DIPHOSPHATE
Authors: VANDERDONK WA YU GX PEREZ L SANCHEZ RJ STUBBE J SAMANO V ROBINS MJ
Citation: Wa. Vanderdonk et al., DETECTION OF A NEW SUBSTRATE-DERIVED RADICAL DURING INACTIVATION OF RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA-COLI BY GEMCITABINE 5'-DIPHOSPHATE, Biochemistry, 37(18), 1998, pp. 6419-6426
GEMCITABINE 5'-TRIPHOSPHATE IS A STOICHIOMETRIC MECHANISM-BASED INHIBITOR OF LACTOBACILLUS-LEICHMANNII RIBONUCLEOSIDE TRIPHOSPHATE REDUCTASE - EVIDENCE FOR THIYL RADICAL-MEDIATED NUCLEOTIDE RADICAL FORMATION
Authors: SILVA DJ STUBBE J SAMANO V ROBINS MJ
Citation: Dj. Silva et al., GEMCITABINE 5'-TRIPHOSPHATE IS A STOICHIOMETRIC MECHANISM-BASED INHIBITOR OF LACTOBACILLUS-LEICHMANNII RIBONUCLEOSIDE TRIPHOSPHATE REDUCTASE - EVIDENCE FOR THIYL RADICAL-MEDIATED NUCLEOTIDE RADICAL FORMATION, Biochemistry, 37(16), 1998, pp. 5528-5535
WHAT ARE THE PRACTICAL LIMITS FOR DETECTION OF MINOR NUCLEOSIDE REACTION-PRODUCTS WITH HPLC (UV DETECTION), 1H NMR, AND TLC (UV DETECTION)
Authors: ROBINS MJ SARKER S WNUK SF
Citation: Mj. Robins et al., WHAT ARE THE PRACTICAL LIMITS FOR DETECTION OF MINOR NUCLEOSIDE REACTION-PRODUCTS WITH HPLC (UV DETECTION), 1H NMR, AND TLC (UV DETECTION), Nucleosides & nucleotides, 17(4), 1998, pp. 785-790
SYNTHESIS OF HOMOLOGATED HALOVINYL DERIVATIVES FROM ARISTEROMYCIN ANDTHEIR INHIBITION OF HUMAN PLACENTAL S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE
Authors: WNUK SF YUAN CS BORCHARDT RT ROBINS MJ
Citation: Sf. Wnuk et al., SYNTHESIS OF HOMOLOGATED HALOVINYL DERIVATIVES FROM ARISTEROMYCIN ANDTHEIR INHIBITION OF HUMAN PLACENTAL S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE, Nucleosides & nucleotides, 17(1-3), 1998, pp. 99-113
NUCLEIC-ACID RELATED-COMPOUNDS - 101 - S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE DOES NOT HYDRATE (5'-FLUORO)VINYL OR (6'-HALO)HOMOVINYL ANALOGS DERIVED FROM 3'-DEOXYADENOSINE OR 3'-(CHLORO OR FLUORO)-3'-DEOXYADENOSINE
Authors: ROBINS MJ NESCHADIMENKO V RO BO YUAN CS BORCHARDT RT WNUK SF
Citation: Mj. Robins et al., NUCLEIC-ACID RELATED-COMPOUNDS - 101 - S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE DOES NOT HYDRATE (5'-FLUORO)VINYL OR (6'-HALO)HOMOVINYL ANALOGS DERIVED FROM 3'-DEOXYADENOSINE OR 3'-(CHLORO OR FLUORO)-3'-DEOXYADENOSINE, Journal of organic chemistry, 63(4), 1998, pp. 1205-1211
NUCLEIC-ACID RELATED-COMPOUNDS - 105 - SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES FROM RIBONUCLEOSIDE CYCLIC 2',3'-(SULFATES OR PHOSPHATES) OR 2',3'-DIMESYLATES VIA REDUCTIVE ELIMINATION WITH SODIUMNAPHTHALENIDE
Authors: ROBINS MJ LEWANDOWSKA E WNUK SF
Citation: Mj. Robins et al., NUCLEIC-ACID RELATED-COMPOUNDS - 105 - SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES FROM RIBONUCLEOSIDE CYCLIC 2',3'-(SULFATES OR PHOSPHATES) OR 2',3'-DIMESYLATES VIA REDUCTIVE ELIMINATION WITH SODIUMNAPHTHALENIDE, Journal of organic chemistry, 63(21), 1998, pp. 7375-7381
SYNTHESIS OF (S)-5-(4,5-DIHYDROXYPENTYL)URACIL FROM PSEUDOURIDINE ANDCLARIFICATION OF STEREOCHEMISTRY
Authors: MAEBA I MORISHITA N FRANCOM P ROBINS MJ
Citation: I. Maeba et al., SYNTHESIS OF (S)-5-(4,5-DIHYDROXYPENTYL)URACIL FROM PSEUDOURIDINE ANDCLARIFICATION OF STEREOCHEMISTRY, Journal of organic chemistry, 63(21), 1998, pp. 7539-7541
INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE AND ANTIVIRAL ACTIVITY WITH ',6',6'-TETRADEHYDRO-6'-DEOXY-6'-HALOHOMOADENOSINE ANALOGS (4'-HALOACETYLENE ANALOGS DERIVED FROM ADENOSINE)
Authors: ROBINS MJ WNUK SF YANG XD YUAN CS BORCHARDT RT BALZARINI J DECLERCQ E
Citation: Mj. Robins et al., INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE AND ANTIVIRAL ACTIVITY WITH ',6',6'-TETRADEHYDRO-6'-DEOXY-6'-HALOHOMOADENOSINE ANALOGS (4'-HALOACETYLENE ANALOGS DERIVED FROM ADENOSINE), Journal of medicinal chemistry, 41(20), 1998, pp. 3857-3864
DISCOVERY OF TYPE-II (COVALENT) INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE INVOLVING ITS HYDROLYTIC ACTIVITY - SYNTHESIS AND EVALUATION OF DIHALOHOMOVINYL NUCLEOSIDE ANALOGS DERIVED FROM ADENOSINE
Authors: WNUK SF MAO Y YUAN CS BORCHARDT RT ANDREI G BALZARINI J DECLERCQ E ROBINS MJ
Citation: Sf. Wnuk et al., DISCOVERY OF TYPE-II (COVALENT) INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE INVOLVING ITS HYDROLYTIC ACTIVITY - SYNTHESIS AND EVALUATION OF DIHALOHOMOVINYL NUCLEOSIDE ANALOGS DERIVED FROM ADENOSINE, Journal of medicinal chemistry, 41(16), 1998, pp. 3078-3083
A NOVEL MECHANISM-BASED INHIBITOR O-5',6'-DIDEHYDRO-6'-DEOXY-6'-FLUOROHOMOADENOSINE) THAT COVALENTLY MODIFIES HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE
Authors: YUAN CS WNUK SF ROBINS MJ BORCHARDT RT
Citation: Cs. Yuan et al., A NOVEL MECHANISM-BASED INHIBITOR O-5',6'-DIDEHYDRO-6'-DEOXY-6'-FLUOROHOMOADENOSINE) THAT COVALENTLY MODIFIES HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE, The Journal of biological chemistry, 273(29), 1998, pp. 18191-18197
RIBONUCLEOTIDE REDUCTASES - RADICAL ENZYMES WITH SUICIDAL TENDENCIES
Authors: STUBBE J VANDERDONK W PEREZ L LAWRENCE C SILVA DJ MCCARTHY JR ROBINS MJ
Citation: J. Stubbe et al., RIBONUCLEOTIDE REDUCTASES - RADICAL ENZYMES WITH SUICIDAL TENDENCIES, The FASEB journal, 11(9), 1997, pp. 872-872
A NOVEL MECHANISM-BASED INHIBITOR ROMO-5',6'-DIDEHYDRO-DEOXY-6'-FLUOROHOMOADENOSINE) THAT COVALENTLY MODIFIES HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE
Authors: YUAN CS WNUK SF ROBINS MJ BORCHARDT RT
Citation: Cs. Yuan et al., A NOVEL MECHANISM-BASED INHIBITOR ROMO-5',6'-DIDEHYDRO-DEOXY-6'-FLUOROHOMOADENOSINE) THAT COVALENTLY MODIFIES HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE, The FASEB journal, 11(9), 1997, pp. 949-949
INACTIVATION OF RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA-COLI BY GEMCITABINE 5'-DIPHOSPHATE
Authors: PEREZ L VANDERDONK WA STUBBE J SAMANO V ROBINS MJ
Citation: L. Perez et al., INACTIVATION OF RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA-COLI BY GEMCITABINE 5'-DIPHOSPHATE, The FASEB journal, 11(9), 1997, pp. 1714-1714
MECHANISM-BASED INACTIVATION OF THE ADENOSYLCOBALAMIN-DEPENDENT RIBONUCLEOTIDE REDUCTASE FROM L-LEICHMANNII BY 2'-ARA-2'-AZIDO-2'-DEOXY ADENOSINE-5'-TRIPHOSPHATE - OBSERVATION OF PARAMAGNETIC INTERMEDIATES
Authors: ASHLEY GW LAWRENCE CC STUBBE J ROBINS MJ
Citation: Gw. Ashley et al., MECHANISM-BASED INACTIVATION OF THE ADENOSYLCOBALAMIN-DEPENDENT RIBONUCLEOTIDE REDUCTASE FROM L-LEICHMANNII BY 2'-ARA-2'-AZIDO-2'-DEOXY ADENOSINE-5'-TRIPHOSPHATE - OBSERVATION OF PARAMAGNETIC INTERMEDIATES, Tetrahedron, 53(35), 1997, pp. 12005-12016
NUCLEIC-ACID RELATED-COMPOUNDS .94. REMARKABLY HIGH STEREOSELECTIVE REDUCTIONS OF 2'-KETONUCLEOSIDE AND 3'-KETONUCLEOSIDE DERIVATIVES TO GIVE ARABINO, RIBO, AND XYLOFURANOSYL NUCLEOSIDES WITH HYDROGEN ISOTOPESAT C2' AND C3'
Authors: ROBINS MJ SARKER S SAMANO V WNUK SF
Citation: Mj. Robins et al., NUCLEIC-ACID RELATED-COMPOUNDS .94. REMARKABLY HIGH STEREOSELECTIVE REDUCTIONS OF 2'-KETONUCLEOSIDE AND 3'-KETONUCLEOSIDE DERIVATIVES TO GIVE ARABINO, RIBO, AND XYLOFURANOSYL NUCLEOSIDES WITH HYDROGEN ISOTOPESAT C2' AND C3', Tetrahedron, 53(2), 1997, pp. 447-456
EFFICIENT REMOVAL OF SUGAR O-TOSYL GROUPS AND HETEROCYCLE HALOGENS FROM PURINE NUCLEOSIDES WITH SODIUM NAPHTHALENIDE
Authors: LEWANDOWSKA E NESCHADIMENKO V WNUK SF ROBINS MJ
Citation: E. Lewandowska et al., EFFICIENT REMOVAL OF SUGAR O-TOSYL GROUPS AND HETEROCYCLE HALOGENS FROM PURINE NUCLEOSIDES WITH SODIUM NAPHTHALENIDE, Tetrahedron, 53(18), 1997, pp. 6295-6302
ANTICANCER AND ANTIVIRAL EFFECTS AND INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE WITH 5'-CARBOXALDEHYDES AND OXIMES SYNTHESIZED FROM ADENOSINE AND SUGAR-MODIFIED ANALOGS
Authors: WNUK SF YUAN CS BORCHARDT RT BALZARINI J DECLERCQ E ROBINS MJ
Citation: Sf. Wnuk et al., ANTICANCER AND ANTIVIRAL EFFECTS AND INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE WITH 5'-CARBOXALDEHYDES AND OXIMES SYNTHESIZED FROM ADENOSINE AND SUGAR-MODIFIED ANALOGS, Journal of medicinal chemistry, 40(11), 1997, pp. 1608-1618
SYNTHESIS OF SUGAR-MODIFIED 2,6-DIAMINOPURINE AND GUANINE NUCLEOSIDESFROM GUANOSINE VIA TRANSFORMATIONS OF 2-AMINOADENOSINE AND ENZYMATIC DEAMINATION WITH ADENOSINE-DEAMINASE
Authors: ROBINS MJ ZOU RM HANSSKE F WNUK SF
Citation: Mj. Robins et al., SYNTHESIS OF SUGAR-MODIFIED 2,6-DIAMINOPURINE AND GUANINE NUCLEOSIDESFROM GUANOSINE VIA TRANSFORMATIONS OF 2-AMINOADENOSINE AND ENZYMATIC DEAMINATION WITH ADENOSINE-DEAMINASE, Canadian journal of chemistry, 75(6), 1997, pp. 762-767
THE MECHANISM OF INACTIVATION OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE BY (E)-4',5'DIDEHYDRO-5'-METHOXYADENOSINE AND ADENOSINE 5'-CARBOXALDEHYDE OXIME
Authors: HUANG H YUAN CS WNUK SF ROBINS MJ BORCHARDT RT
Citation: H. Huang et al., THE MECHANISM OF INACTIVATION OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE BY (E)-4',5'DIDEHYDRO-5'-METHOXYADENOSINE AND ADENOSINE 5'-CARBOXALDEHYDE OXIME, Archives of biochemistry and biophysics, 343(1), 1997, pp. 109-117
ELIMINATION OF CHLORINE (RADICAL) OR TOSYLATE (ANION) FROM C2' OF NUCLEOSIDE C3' FREE-RADICALS AS MODEL REACTIONS POSTULATED TO OCCUR AT THE ACTIVE-SITE OF RIBONUCLEOTIDE REDUCTASES
Authors: ROBINS MJ GUO ZQ WNUK SF
Citation: Mj. Robins et al., ELIMINATION OF CHLORINE (RADICAL) OR TOSYLATE (ANION) FROM C2' OF NUCLEOSIDE C3' FREE-RADICALS AS MODEL REACTIONS POSTULATED TO OCCUR AT THE ACTIVE-SITE OF RIBONUCLEOTIDE REDUCTASES, Journal of the American Chemical Society, 119(15), 1997, pp. 3637-3638
RIBONUCLEOTIDE REDUCTASE - NO LONGER CONFUSING BUT STILL AMAZING
Authors: VANDERDONK W LICHT S DASALVA D MCCARTHY J ROBINS MJ STUBBE J
Citation: W. Vanderdonk et al., RIBONUCLEOTIDE REDUCTASE - NO LONGER CONFUSING BUT STILL AMAZING, The FASEB journal, 10(6), 1996, pp. 503-503
THE MECHANISMS OF INACTIVATION OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE BY (E)-4',5'-DIDEHYDRO-5'-METHOXYADENOSINE (DMOA) AND ADENOSINE 5'-CARBOXALDEHYDE OXIME (ACAO)
Authors: HUANG H YUAN CS BORCHARDT RT WNUK SF ROBINS MJ
Citation: H. Huang et al., THE MECHANISMS OF INACTIVATION OF HUMAN PLACENTAL S-ADENOSYLHOMOCYSTEINE HYDROLASE BY (E)-4',5'-DIDEHYDRO-5'-METHOXYADENOSINE (DMOA) AND ADENOSINE 5'-CARBOXALDEHYDE OXIME (ACAO), The FASEB journal, 10(6), 1996, pp. 1415-1415
SELECTIVE-INHIBITION OF THE REVERSE TRANSCRIPTION OF DUCK HEPATITIS-BVIRUS BY BINDING OF 2,3-DIDEOXYGUANOSINE 5-TRIPHOSPHATE TO THE VIRAL POLYMERASE
Authors: HOWE AYM ROBINS MJ WILSON JS TYRRELL DLJ
Citation: Aym. Howe et al., SELECTIVE-INHIBITION OF THE REVERSE TRANSCRIPTION OF DUCK HEPATITIS-BVIRUS BY BINDING OF 2,3-DIDEOXYGUANOSINE 5-TRIPHOSPHATE TO THE VIRAL POLYMERASE, Hepatology, 23(1), 1996, pp. 87-96
SYNTHESIS OF 2',3'-FUSED-(3.3.0) GAMMA-BUTYROLACTONE-NUCLEOSIDES AND COUPLING WITH AMINO-NUCLEOSIDES TO GIVE AMIDE-LINKED NUCLEOTIDE-DIMER ANALOGS
Authors: ROBINS MJ SARKER S XIE MQ ZHANG WJ PETERSON MA
Citation: Mj. Robins et al., SYNTHESIS OF 2',3'-FUSED-(3.3.0) GAMMA-BUTYROLACTONE-NUCLEOSIDES AND COUPLING WITH AMINO-NUCLEOSIDES TO GIVE AMIDE-LINKED NUCLEOTIDE-DIMER ANALOGS, Tetrahedron letters, 37(23), 1996, pp. 3921-3924
NUCLEIC-ACID RELATED-COMPOUNDS .93. A SOLUTION FOR THE HISTORIC PROBLEM OF REGIOSELECTIVE SUGAR-BASE COUPLING TO PRODUCE 9-GLYCOSYLGUANINESOR 7-GLYCOSYLGUANINES
Authors: ROBINS MJ ZOU RM GUO ZQ WNUK SF
Citation: Mj. Robins et al., NUCLEIC-ACID RELATED-COMPOUNDS .93. A SOLUTION FOR THE HISTORIC PROBLEM OF REGIOSELECTIVE SUGAR-BASE COUPLING TO PRODUCE 9-GLYCOSYLGUANINESOR 7-GLYCOSYLGUANINES, Journal of organic chemistry, 61(26), 1996, pp. 9207-9212
Risultati: 1-25 | 26-50 | 51-53