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Results: 1-23 |
Results: 23
The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor
Authors: Roth, BL Ernsberger, P Steinberg, S Rao, S Rauser, L Savage, J Hufeisen, S Berridge, MS Muzic, RF
Citation: Bl. Roth et al., The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor, PSYCHOPHAR, 157(1), 2001, pp. 111-114
Rational design, synthesis, and biological evaluation of rigid pyrrolidoneanalogues as potential inhibitors of prostate cancer cell growth
Authors: Qiao, LX Zhao, LY Rong, SB Wu, XW Wang, SM Fujii, T Kazanietz, MG Rauser, L Savage, J Roth, BL Flippen-Anderson, J Kozikowski, AP
Citation: Lx. Qiao et al., Rational design, synthesis, and biological evaluation of rigid pyrrolidoneanalogues as potential inhibitors of prostate cancer cell growth, BIOORG MED, 11(8), 2001, pp. 955-959
Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene
Authors: Runyon, SP Savage, JE Taroua, M Roth, BL Glennon, RA Westkaemper, RB
Citation: Sp. Runyon et al., Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene, BIOORG MED, 11(5), 2001, pp. 655-658
Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor
Authors: Westkaemper, RB Runyon, SP Savage, JE Roth, BL Glennon, RA
Citation: Rb. Westkaemper et al., Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor, BIOORG MED, 11(4), 2001, pp. 563-566
Synthesis of potent and selective dopamine D-4 antagonists as candidate radioligands
Authors: Huang, YY Kegeles, LS Bae, SA Hwang, DR Roth, BL Savage, JE Laruelle, M
Citation: Yy. Huang et al., Synthesis of potent and selective dopamine D-4 antagonists as candidate radioligands, BIOORG MED, 11(11), 2001, pp. 1375-1377
Distribution of serotonin 5-HT2A receptors in afferents of the rat striatum
Authors: Bubser, M Backstrom, JR Sanders-Bush, E Roth, BL Deutch, AY
Citation: M. Bubser et al., Distribution of serotonin 5-HT2A receptors in afferents of the rat striatum, SYNAPSE, 39(4), 2001, pp. 297-304
Cell-type specific effects of endocytosis inhibitors on 5-Hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells
Authors: Gray, JA Sheffler, DJ Bhatnagar, A Woods, JA Hufeisen, SJ Benovic, JL Roth, BL
Citation: Ja. Gray et al., Cell-type specific effects of endocytosis inhibitors on 5-Hydroxytryptamine(2A) receptor desensitization and resensitization reveal an arrestin-, GRK2-, and GRK5-independent mode of regulation in human embryonic kidney 293 cells, MOLEC PHARM, 60(5), 2001, pp. 1020-1030
Discovery of a novel member of the histamine receptor family
Authors: Nguyen, T Shapiro, DA George, SR Setola, V Lee, DK Cheng, R Rauser, L Lee, SP Lynch, KR Roth, BL O'Dowd, BF
Citation: T. Nguyen et al., Discovery of a novel member of the histamine receptor family, MOLEC PHARM, 59(3), 2001, pp. 427-433
Inverse agonist actions of typical and atypical antipsychotic drugs at thehuman 5-hydroxytryptamine(2C) receptor
Authors: Rauser, L Savage, JE Meltzer, HY Roth, BL
Citation: L. Rauser et al., Inverse agonist actions of typical and atypical antipsychotic drugs at thehuman 5-hydroxytryptamine(2C) receptor, J PHARM EXP, 299(1), 2001, pp. 83-89
The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis
Authors: Bhatnagar, A Willins, DL Gray, JA Woods, J Benovic, JL Roth, BL
Citation: A. Bhatnagar et al., The dynamin-dependent, arrestin-independent internalization of 5-hydroxytryptamine 2A (5-HT2A) serotonin receptors reveals differential sorting of arrestins and 5-HT2A receptors during endocytosis, J BIOL CHEM, 276(11), 2001, pp. 8269-8277
N-1-(benzenesulfonyl)tryptamines as novel 5-HT6 antagonists
Authors: Tsai, YC Dukat, M Slassi, A MacLean, N Demchyshyn, L Savage, JE Roth, BL Hufesein, S Lee, M Glennon, RA
Citation: Yc. Tsai et al., N-1-(benzenesulfonyl)tryptamines as novel 5-HT6 antagonists, BIOORG MED, 10(20), 2000, pp. 2295-2299
Agonist high and low affinity state ratios predict drug intrinsic activityand a revised ternary complex mechanism at serotonin 5-HT2A and 5-HT2C receptors
Authors: Egan, C Grinde, E Dupre, A Roth, BL Hake, M Teitler, M Herrick-Davis, K
Citation: C. Egan et al., Agonist high and low affinity state ratios predict drug intrinsic activityand a revised ternary complex mechanism at serotonin 5-HT2A and 5-HT2C receptors, SYNAPSE, 35(2), 2000, pp. 144-150
Differential modes of agonist binding to 5-Hydroxytryptamine(2A) serotoninreceptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5
Authors: Shapiro, DA Kristiansen, K Kroeze, WK Roth, BL
Citation: Da. Shapiro et al., Differential modes of agonist binding to 5-Hydroxytryptamine(2A) serotoninreceptors revealed by mutation and molecular modeling of conserved residues in transmembrane region 5, MOLEC PHARM, 58(5), 2000, pp. 877-886
A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT2A serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism
Authors: Kristiansen, K Kroeze, WK Willins, DL Gelber, EI Savage, JE Glennon, RA Roth, BL
Citation: K. Kristiansen et al., A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT2A serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism, J PHARM EXP, 293(3), 2000, pp. 735-746
2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors
Authors: Glennon, RA Lee, M Rangisetty, JB Dukat, M Roth, BL Savage, JE McBride, A Rauser, L Hufeisen, S Lee, DKH
Citation: Ra. Glennon et al., 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors, J MED CHEM, 43(5), 2000, pp. 1011-1018
Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications
Authors: Rothman, RB Baumann, MH Savage, JE Rauser, L McBride, A Hufeisen, SJ Roth, BL
Citation: Rb. Rothman et al., Evidence for possible involvement of 5-HT2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications, CIRCULATION, 102(23), 2000, pp. 2836-2841
What's all the RAVE about receptor internalization?
Authors: Roth, BL Willins, DL
Citation: Bl. Roth et Dl. Willins, What's all the RAVE about receptor internalization?, NEURON, 23(4), 1999, pp. 629-631
Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo
Authors: Willins, DL Berry, SA Alsayegh, L Backstrom, JR Sanders-Bush, E Friedman, L Roth, BL
Citation: Dl. Willins et al., Clozapine and other 5-hydroxytryptamine-2A receptor antagonists alter the subcellular distribution of 5-hydroxytryptamine-2A receptors in vitro and in vivo, NEUROSCIENC, 91(2), 1999, pp. 599-606
Engineering a region of bulk tolerance in the 5-HT2A receptor
Authors: Westkaemper, RB Hyde, EG Choudhary, MS Khan, N Gelbar, EI Glennon, RA Roth, BL
Citation: Rb. Westkaemper et al., Engineering a region of bulk tolerance in the 5-HT2A receptor, EUR J MED C, 34(5), 1999, pp. 441-447
Structure and function of the third intracellular loop of the 5-hydroxytryptamine(2A) receptor: The third intracellular loop is alpha-helical and binds purified arrestins
Authors: Gelber, EI Kroeze, WK Willins, DL Gray, JA Sinar, CA Hyde, EG Gurevich, V Benovic, J Roth, BL
Citation: Ei. Gelber et al., Structure and function of the third intracellular loop of the 5-hydroxytryptamine(2A) receptor: The third intracellular loop is alpha-helical and binds purified arrestins, J NEUROCHEM, 72(5), 1999, pp. 2206-2214
9-(aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist
Authors: Westkaemper, RB Runyon, SP Bondarev, ML Savage, JE Roth, BL Glennon, RA
Citation: Rb. Westkaemper et al., 9-(aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist, EUR J PHARM, 380(1), 1999, pp. R5-R7
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression
Authors: Rajkowska, G Miguel-Hidalgo, JJ Wei, JR Dilley, G Pittman, SD Meltzer, HY Overholser, JC Roth, BL Stockmeier, CA
Citation: G. Rajkowska et al., Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression, BIOL PSYCHI, 45(9), 1999, pp. 1085-1098
Serotonin 5-HT2A receptors: Molecular biology and mechanisms of regulation
Authors: Roth, BL Berry, SA Kroeze, WK Willins, DL Kristiansen, K
Citation: Bl. Roth et al., Serotonin 5-HT2A receptors: Molecular biology and mechanisms of regulation, CR R NEUR, 12(4), 1998, pp. 319-338
Risultati: 1-23 |